1. Relapse

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    1. Mentioned In 72 Articles

    2. PIM Kinases Are a Potential Prognostic Biomarker and Therapeutic Target in Neuroblastoma

      PIM Kinases Are a Potential Prognostic Biomarker and Therapeutic Target in Neuroblastoma
      ...Institute, Amsterdam, the Netherlands. The majority of high-risk neuroblastoma patients are refractory to, or relapse on, current treatment regimens, resulting in 5-year survival rates of less than 50%. This emphasizes t...
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    3. PIM kinases are a potential prognostic biomarker and therapeutic target in neuroblastoma.

      ...o identify novel therapeutic targets. The majority of high-risk neuroblastoma patients are refractory to, or relapse on current treatment regimens, resulting in 5-year survival rates of less than 50%. This emphasizes th...
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    4. The novel kinase inhibitor ponatinib is an effective anti-angiogenic agent against neuroblastoma.

      ...re needed to improve these outcomes. Background High-risk neuroblastoma has poor outcomes with high rates of relapse despite aggressive treatment, and novel therapies are needed to improve these outcomes. Ponatinib is a...
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      Mentions: Treatment Relapse
    5. Seattle Children's Opens CD22 CAR T-Cell Immunotherapy Trial for Children and Young Adults Whose Leukemia Escapes CD19 CAR T-Cell Therapy

      Seattle Children's Opens CD22 CAR T-Cell Immunotherapy Trial for Children and Young Adults Whose Leukemia Escapes CD19 CAR T-Cell Therapy
      ...to three years. “Leukemia cells evolve in order to find ways to survive,” said Summers. “For the patients who relapse with CD22-positive leukemia, we are very pleased to now be able to offer a treatment option that will ...
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    6. Seattle Children's opens CD22 CAR T-cell immunotherapy trial for children and young adults

      Seattle Children's opens CD22 CAR T-cell immunotherapy trial for children and young adults
      ...to three years. "Leukemia cells evolve in order to find ways to survive," said Summers. "For the patients who relapse with CD22-positive leukemia, we are very pleased to now be able to offer a treatment option that will ...
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  2. Quotes about Relapse

    1. The strategies are key as they give us an indication of the evolutionary capacity a tumour has at the time of discovery. Patients with the first two variants generally have good outcomes, while the latter two strategies are associated with risk of relapse
      In Childhood cancer: The four survival strategies of tumour cells
    2. The strategies are key as they give us an indication of the evolutionary capacity a tumor has at the time of discovery. Patients with the first two variants generally have good outcomes, while the latter two strategies are associated with risk of relapse
      In Study shows four survival strategies of tumor cells in childhood cancer
    3. The same two strategies were found when we analysed relapse tumours. It seems that some cancer cells are programmed from the outset to single-handedly create a relapse.
      In Study identifies four tumor survival strategies in childhood cancer