1. PD-1

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    1. Mentioned In 29 Articles

    2. PD-L1 is a therapeutic target of the Bromodomain inhibitor JQ1 and, combined with HLA class I, a promising prognostic biomarker in neuroblastoma.

      ... control the expression of PD-L1 in neuroblastoma cells both in vitro and in vivo. Consistently, abundance of PD-L1 transcript correlates with MYC expression in primary neuroblastoma. The combination of PD-L1 and HLA cla...
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      Mentions: MYCN PD-1
    3. Transfer of Allogeneic CD4+ T Cells Rescues CD8+ T Cells in Anti-PD-L1-Resistant Tumors Leading to Tumor Eradication

      Adoptively transferred CD8+ T cells can stabilize the size of solid tumors over long periods of time by exclusively recognizing antigen cross-presented on tumor stroma. However, these tumors eventually escape T-cell–mediated growth control. The aim of this study was to eradicate such persistent cancers. In our model, the SIYRYYGL antigen is expressed by cancer cells that lack the MHC-I molecule Kb needed for direct presentation, but the antigen is ...
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      Mentions: PD-1
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  2. Quotes about PD-1

    1. We are establishing a broad base of clinical evidence with our anti-PD-1 therapy, KEYTRUDA, as monotherapy across different types of cancer.
      In TetraLogic and Merck to Collaborate on the Evaluation of Birinapant in Combination with KEYTRUDA® (pembrolizumab) in Solid Tumors
    2. We still don't know the molecular signals downstream of PD-1 in vivo or how PD-1 signals intersect with other immunotherapies.
      In Homing in on What's Wearing Out T Cells
    3. We now have many antibody drugs [such as pembrolizumab and ipilimumab] that target immune checkpoints such as PD-1, PD-L1, CTLA4, and other immune-regulatory pathways. However, these types of drugs have some overlooked drawbacks that can limit their effectiveness.
      In Small Protein Engineered to Target PD-L1 is More Potent Than Anti-PD-L1 Antibody Immunotherapeutic