1. PD-1

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    1. Mentioned In 23 Articles

    2. PD-L1 is a therapeutic target of the Bromodomain inhibitor JQ1 and, combined with HLA class I, a promising prognostic biomarker in neuroblastoma.

      ... control the expression of PD-L1 in neuroblastoma cells both in vitro and in vivo. Consistently, abundance of PD-L1 transcript correlates with MYC expression in primary neuroblastoma. The combination of PD-L1 and HLA cla...
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      Mentions: MYCN PD-1
    3. Transfer of Allogeneic CD4+ T Cells Rescues CD8+ T Cells in Anti-PD-L1-Resistant Tumors Leading to Tumor Eradication

      Adoptively transferred CD8+ T cells can stabilize the size of solid tumors over long periods of time by exclusively recognizing antigen cross-presented on tumor stroma. However, these tumors eventually escape T-cell–mediated growth control. The aim of this study was to eradicate such persistent cancers. In our model, the SIYRYYGL antigen is expressed by cancer cells that lack the MHC-I molecule Kb needed for direct presentation, but the antigen is ...
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      Mentions: PD-1
    4. Combination viroimmunotherapy with checkpoint inhibition to treat glioma, based on location-specific tumor profiling.

      Combination viroimmunotherapy with checkpoint inhibition to treat glioma, based on location-specific tumor profiling. Neuro Oncol. 2015 Sep 26; Authors: Cockle JV, Rajani K, Zaidi S, Kottke T, Thompson J, Diaz RM, Shim K, Peterson T, Parney IF, Short S, Selby P, Ilett E, Melcher A, Vile R
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    5. 1-15 of 23 1 2 »
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  2. Quotes about PD-1

    1. We still don't know the molecular signals downstream of PD-1 in vivo or how PD-1 signals intersect with other immunotherapies.
      In Homing in on What's Wearing Out T Cells
    2. We are establishing a broad base of clinical evidence with our anti-PD-1 therapy, KEYTRUDA, as monotherapy across different types of cancer.
      In TetraLogic and Merck to Collaborate on the Evaluation of Birinapant in Combination with KEYTRUDA® (pembrolizumab) in Solid Tumors
    3. Plans are to advance the project into multiple combination trials pending completion of the dose escalation part of the ongoing phase I trial. HuMax-IL8 will then potentially be combined with a PD-1/PD-L1 inhibitor, cancer vaccine and with chemotherapy in breast, lung and other cancers.
      In Decision Taken to Escalate to the Next Dose Level in a Clinical Trial With HuMax-IL8 in Patients With Advanced Solid Tumors Ongoing at the NCI