1. Nanoparticles

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    1. Mentioned In 29 Articles

    2. Enhanced Intratumoral Delivery of SN38 as a Tocopherol Oxyacetate Prodrug Using Nanoparticles in a Neuroblastoma Xenograft Model

      Enhanced Intratumoral Delivery of SN38 as a Tocopherol Oxyacetate Prodrug Using Nanoparticles in a Neuroblastoma Xenograft Model
      ... toxicities, so more effective, less toxic therapy is needed. One approach is to target drugs to tumors using nanoparticles, which take advantage of the enhanced permeability of tumor vasculature. Experimental Design: SN...
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      Mentions: Nanoparticles
    3. Enhanced Intratumoral Delivery of SN38 as a Tocopherol Oxyacetate Prodrug Using Nanoparticles in a Neuroblastoma Xenograft Model.

      ...ve metabolite of irinotecan (CPT-11), is a potent therapeutic agent that is readily encapsulated in polymeric nanoparticles (NPs). Tocopherol oxyacetate (TOA) is a hydrophobic mitocan that was linked to SN38 to significa...
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      Mentions: Nanoparticles
    4. Composite iron oxide-Prussian blue nanoparticles for magnetically guided T1-weighted magnetic resonance imaging and photothermal therapy of tumors.

      ...properties and safety profiles of the constituent Fe3O4 nanoparticles and gadolinium-containing Prussian blue nanoparticles. The Fe3O4@GdPB nanoparticles function both as effective MRI contrast agents and PTT agents as d...
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    5. Targeted drug distribution in tumor extracellular fluid of GD2-expressing neuroblastoma patient-derived xenografts using SN-38-loaded nanoparticles conjugated to the monoclonal antibody 3F8.

      ...tomas recur because of chemoresistance. Here we encapsulated the topoisomerase-I inhibitor SN-38 in polymeric nanoparticles (NPs) surface-decorated with the anti-GD2 mouse mAb 3F8 at a mean density of seven antibody mole...
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    6. Theranostics: Optical Imaging and Gene Therapy with Neuroblastoma-Targeting Polymeric Nanoparticles for Potential Theranostic Applications (Small 9/2016).

      ...as a tumor-targeting theranostic agent by I. C. Kwon, K. Y. Lee, and co-workers. Ligand-modified, gene-loaded nanoparticles (NPs) are designed and prepared as a tumor-targeting theranostic agent by I. C. Kwon, K. Y. Lee,...
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    7. High specificity targeting and detection of human neuroblastoma using multifunctional anti-GD2 iron-oxide nanoparticles.

      ...lastoma with reduced nonspecific immune interactions, was conjugated to hydroxyethyl starch-coated iron-oxide nanoparticles. Targeting capability in vitro and in vivo was assessed by immunofluorescence, electron microsco...
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    8. Magnetic nanoparticles could be key to effective immunotherapy

      "Schneck says that the use of naive T cells could make the new technique useful for more patients than another immunotherapy now being tested, which relies on other white blood cells called tumor-infiltrating lymphocytes. Those cells are already "trained" to fight cancer, and researchers have shown some success isolating some of the cells from tumors, inducing them to divide, and then transferring them back into patients. But, Schneck says, not ...
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  2. Quotes about Nanoparticles

    1. One could use the results from this paper to think about how to leverage these findings into improved nanoparticle delivery vehicles -- for instance, perhaps new surface ligands for nanoparticles could be engineered to have improved affinity for both surface groups and lipid tails.
      In More than glitter: how gold nanoparticles easily penetrate cells, making them useful for delivering drugs
    2. The properties of the nanoparticles will give you a resonance shift upon a biological binding reaction.
      In Supersensitive Nanodevice Can Detect Extremely Early Cancers
    3. We are very excited at the potential for clinical practice using our enhanced red-emission nanoparticles combined with FDA-approved photodynamic drug therapy to kill malignant cells in deeper tumors.
      In Tuning light to kill deep cancer tumors