1. Genetics

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    1. Mentioned In 24 Articles

    2. Children's Hospital of Philadelphia to Lead New Pediatric Data Resource Center for Research in Childhood Cancer and Structural Birth Defects

      Children's Hospital of Philadelphia to Lead New Pediatric Data Resource Center for Research in Childhood Cancer and Structural Birth Defects
      ...hip with patients and families and the integration of efforts across disciplines, from surgery to oncology to genetics, within and across institutions, that these efforts are made possible," noted Phillip (Jay) Storm, MD...
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    3. Integrative genomics reveals hypoxia inducible genes that are associated with a poor prognosis in neuroblastoma patients.

      "Analysis of 5-hydroxymethylcytosine and ENCODE data indicate that at least five of these nine genes have an increase in 5-hydroxymethylcytosine and a more open chromatin structure in hypoxia versus normoxia and are putative targets of hypoxia inducible factor (HIF) as they contain HIF binding sites in their regulatory regions. Four of these genes are key components of the glycolytic pathway and another three are directly involved in cellular metabolism. We ...
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      Mentions: Genetics
    4. Genetics Home Reference: neuroblastoma

      Neuroblastoma and other cancers occur when a buildup of genetic mutations in critical genes—those that control cell growth and division (proliferation) or maturation (differentiation)—allow cells to grow and divide uncontrollably to form a tumor. In most cases, these genetic changes are acquired during a person's lifetime and are called somatic mutations. Somatic mutations are present only in certain cells and are not inherited.
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      Mentions: ALK MYCN PHOX2B
    5. 1-15 of 24 1 2 »
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  2. About Genetics

    Genetics, genomics

  3. Quotes about Genetics

    1. There is so much talk about understanding the connection between genetics and disease and finding personalized therapies.
      In Non-coding half of human genome unlocked with novel sequencing technique
    2. Genetics has been extremely useful to guiding treatment, but in many cases tumor genetics are ambiguous or do not reveal a mutation that informs a therapeutic strategy.
      In Direct Drug Screening of Patient Biopsies Could Overcome Resistance to Targeted Therapy
    3. Associating patient genetics with tumor genotype is a relatively new idea.
      In New research points to potential for more targeted treatments of neuroblastoma tumors