1. ALK

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    1. Mentioned In 129 Articles

    2. Metachronous Medulloblastoma in a Child With Successfully Treated Neuroblastoma: Case Report and Novel Findings of DNA Sequencing.

      ...OR inhibitors. Germline single nucleotide variants were also identified in multiple genes involved in cancer (ALK, FGFR3, FLT3/4, HNF1A, NCOR1, and NOTCH2/3), cancer predisposition (TP53, TSC1, and BRCA1/2), and genes in...
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      Mentions: ALK
    3. Conformational Transition of Key Structural Features Involved in Activation of ALK Induced by Two Neuroblastoma Mutations and ATP Binding: Insight from Accelerated Molecular Dynamics Simulations.

      ... Kinase (ALK) has been observed to be implicated in developing of tumor progress. The activation mechanism of ALK is proposed to be similar with other receptor tyrosine kinase (RTK), but the distinct static X-ray crystal...
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      Mentions: ALK
    4. Good clinical response to alectinib, a second generation ALK inhibitor, in refractory neuroblastoma

      I have read and accept the Wiley Online Library Terms and Conditions of Use. I have read and accept the Wiley Online Library Terms and Conditions of Use. Use the link below to share a full-text version of this article with your friends and colleagues. Learn more.
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      Mentions: Refractory ALK
    5. The absence of a novel intron 19-retaining ALK transcript (ALK-I19) and MYCN amplification correlates with an excellent clinical outcome in neuroblastoma patients.

      ...ts (FS-ALK) and a significant reduction in cell growth. We also demonstrate that ALK-I19 is a precursor of FS-ALK. ALK-I19 was detected in 14/37 (38%) tumors from patients with newly diagnosed NB. ALK-I19 expression corr...
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      Mentions: ALK MYCN
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  2. Quotes about ALK

    1. Exploitation of ALK as a therapeutic target in neuroblastoma
      In ANR 2010 ~ Days 1 & 2
    2. The updated data from the ongoing trial continue to demonstrate the anti-tumor activity of AP26113 in patients with crizotinib-resistant ALK rearranged NSCLC, as well as TKI-naïve ALK rearranged NSCLC.
      In ARIAD Presents Updated Clinical Data on AP26113 in Patients with ALK+ Non-Small Cell Lung Cancer
    3. This will give oncologists a way to avoid overtreating or undertreating each patient, by knowing whether crizotinib or similar ALK inhibitors will be necessary and effective.
      In Classification of Gene Mutations in a Children's Cancer May Point to Improved Treatments