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    1. Fighting cancer with immunotherapy: Signaling molecule causes regression of blood vessels

      Fighting cancer with immunotherapy: Signaling molecule causes regression of blood vessels

      Immunotherapy with T-cells offers great hope to people suffering from cancer. Some initial successes have already been made in treating blood cancer, but treating solid tumors remains a major challenge. The signaling molecule interferon gamma, which is produced by T-cells, plays a key role in the therapy. It cuts off the blood supply to tumors, as a new study reveals.

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    2. Common nerve protein elevated in aggressive neuroblastomas

      "Because of their neuronal origin, neuroblastomas synthesize and release neuropeptide Y (NPY), a small protein normally secreted from mature nerves. In previous research, Kitlinska and her colleagues have shown that NPY, acting via its Y2 and Y5 receptors (Y2R and Y5R), is crucial for maintaining neuroblastoma growth and protecting the tumors from chemotherapy.

      "To confirm the clinical relevance of our earlier work and assess NPY and its receptors as potential prognostic factors, we performed clinical study on tissue samples and serum from 87 neuroblastoma patients," Kitlinska explains.

      "We have found that NPY is released from aggressive neuroblastoma tumors into the ...

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    3. Almost one-third of families of children with cancer have unmet basic needs during treatment

      Almost one-third of families whose children were being treated for cancer faced food, housing or energy insecurity and one-quarter lost more than 40 percent of household income, according to a new American study. The study follows emerging research in pediatric oncology finding that low-income status predicts poor adherence to oral chemotherapy and decreased overall survival.

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    4. Magnetic nanoparticles could be key to effective immunotherapy

      "Schneck says that the use of naive T cells could make the new technique useful for more patients than another immunotherapy now being tested, which relies on other white blood cells called tumor-infiltrating lymphocytes. Those cells are already "trained" to fight cancer, and researchers have shown some success isolating some of the cells from tumors, inducing them to divide, and then transferring them back into patients. But, Schneck says, not all patients are eligible for this therapy, because not all have tumor-infiltrating lymphocytes. By contrast, all people have naive T cells, so patients with cancer could potentially benefit from the ...

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    5. Risks of whole brain radiation therapy added to radiosurgery outweigh benefits for patients with limited brain metastases

      Whole Brain Radiation Therapy (WBRT) is associated with significantly worse cognitive function than radiosurgery, and should no longer be used in the adjuvant setting after radiosurgery to treat cancer patients with brain metastases, according to a large study led by a researcher at The University of Texas MD Anderson Cancer Center.

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      Mentions: Radiotherapy
    6. Gene therapy, surgery could mean eight more months for sickest brain cancer patients

      Houston Methodist Neurological Institute neurosurgeon David Baskin, M.D., is presenting preliminary data from a phase II clinical trial that suggests gene therapy, (AdV-Tk therapy), which uses a mediated herpes simplex virus, combined with a traditional treatment -- surgical resection -- could benefit glioblastoma patients with the worst prognoses.

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    7. Scientists discover new molecules that kill cancer cells and protect healthy cells

      "When the FMD compounds enter a cancer cell, they react strongly and form reactive radicals, which cause the cell to kill itself. When the FMD compounds enter a healthy cell, the cell starts to increase the amount of a protective molecule called glutathione (GSH) in the cell. This protects the cell against chemical toxins, so it is not damaged."

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    8. Using CRISPR, biologists find a way to comprehensively identify anti-cancer drug targets

      Using CRISPR, biologists find a way to comprehensively identify anti-cancer drug targets

      "The short answer is yes. Their paper provides a proof of principle of the method they have devised. In leukemia cells, the CRISPR-based method surveyed about 200 potential targets and successfully identified the six targets already known and validated by pharmaceutical scientists, most of which are at the focus of existing drug development efforts; and found an additional 19 targets never before recognized. "This is just a single demonstration," says Vakoc. "More broadly, what we provide is a way to comprehensively identify specific vulnerabilities in cancer cells, across cancer types."

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    9. Study may suggest new strategies for myelodysplastic syndromes treatment

      "The team's mouse and human cell study found that DNA damage caused by dysfunctional telomeres resulted in repressed expression of a gene called SRSF2. SRSF2 is a RNA splicing gene that plays a role in cellular processes. This change impacted blood cells named CMPs (common myeloid progenitors), affecting their ability to differentiate or fully mature.  "This study established an intimate link across telomere biology, aberrant RNA splicing and CMP differentiation," said DiPinho. "This may suggest that strategies to mitigate this DNA damage may be useful for preventing and/or treating MDS."

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      Mentions: Treatment
    10. Uncovering new functions of a gene implicated in cancer growth opens new therapeutic possibilities

      For the first time, researchers have shown that a gene previously implicated in blood vessel formation during embryonic development and tumor growth also induces immune suppression during tumor development. This finding opens the door for new therapeutic approaches and vaccine development in treating patients with melanoma and other advanced-staged cancers.

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    11. T cell receptor ensures Treg functionality

      T cell receptor ensures Treg functionality

      Misdirected immune responses that target the body's own tissue can result in diseases. Regulatory T cells combat this effect by suppressing excessive immune responses and responses against our own bodies. Until now, scientists had been aware of two molecular properties of regulatory T cells that control these functions. Now researchers have shown that signals emitted by T cell receptor on the regulartory T cells' surface are also essential for their identity and suppressive functions.

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      Mentions: T-Cells
    12. Youngest bone marrow transplant patients at higher risk of cognitive decline

      Toddlers who undergo total body irradiation in preparation for bone marrow transplantation are at higher risk for a decline in IQ and may be candidates for stepped up interventions to preserve intellectual functioning, investigators report. The results clarify the risk of intellectual decline faced by children, teenagers and young adults following bone marrow transplantation. The procedure is used for treatment of cancer and other diseases.

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    13. Getting antibodies into shape to fight cancer

      The precise shape of an antibody makes a big difference to how it can stimulate the body's immune system to fight cancer, paving the way for much more effective treatments, researchers have found. The latest types of treatment for cancer are designed to switch on the immune system, allowing the patient's own immune cells to attack and kill cancerous cells, when normally the immune cells would lie dormant.

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    1-24 of 54 1 2 3 »
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