1. Articles from EurekAlert!

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    1. Nanoparticles give immune cells a boost

      Nanoparticles give immune cells a boost

      ( Massachusetts Institute of Technology ) MIT researchers have devised a novel way to boost the effectiveness of T cell therapy against solid tumors. By attaching nanoparticle 'backpacks' carrying immune-stimulating drugs directly to T cells, the MIT engineers showed that they could enhance those T cells' response without inducing harmful side effects.

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    2. Rigorous study finds widely used treatment for infection fails young cancer patients

      Rigorous study finds widely used treatment for infection fails young cancer patients

      ( St. Jude Children's Research Hospital ) St. Jude Children's Research Hospital found ethanol-lock therapy failed to prevent new or recurring infections in cancer patients with central venous catheters and was associated with increased complications.

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      Mentions: Treatment
    3. Childhood cancer: The four survival strategies of tumor cells

      Childhood cancer: The four survival strategies of tumor cells

      ( Lund University ) Cancer cells in children tend to develop by following four main trajectories -- and two of them are linked to relapse of the disease, research led by Lund University in Sweden shows. The four strategies can occur simultaneously in a single tumor, according to the study that is now published in Nature Genetics.

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      Mentions: Relapse Genetics
    4. Epigenetic analysis: Giving the right name to a tumor

      Epigenetic analysis: Giving the right name to a tumor

      ( Heidelberg University Hospital and Medical Faculty ) Scientists from the 'Hopp Children's Cancer Center at the NCT Heidelberg' (KiTZ) and the Neuropathology Department at Heidelberg University Hospital have substantially enhanced the classification of tumors of the central nervous system (CNS) / Physicians will now be able to categorize CNS tumors more precisely into specific risk groups and make therapy decisions on this basis / The method was developed in close collaboration with the German Cancer Consortium (DKTK) / Publication in Nature.

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    5. Oestrogen causes neuroblastoma cells to mature into neurons

      Oestrogen causes neuroblastoma cells to mature into neurons

      ( Karolinska Institutet ) The female sex hormone oestrogen can perform an important role in neuroblastoma, a form of cancer mainly affecting young children. In laboratory experiments, researchers at Karolinska Institutet in Sweden demonstrate that oestrogen treatment and overexpression of the oestrogen receptor cause malignant neuroblastoma cells to mature into neuron-like cells. The study, which is published in PNAS, gives hope of new treatment possibilities.

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      Mentions: Treatment MYCN
    6. New study finds childhood cancer survivors commonly stay at jobs to keep health insurance

      New study finds childhood cancer survivors commonly stay at jobs to keep health insurance

      ( University of Utah Health ) The results of a national cancer survey find a significant number of childhood cancer survivors are worried about keeping their health insurance, to the point of letting it affect their career decisions. The findings were published today in JAMA Oncology.

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    7. Researchers identify gene variants linked to a high-risk children's cancer

      Researchers identify gene variants linked to a high-risk children's cancer

      ( Children's Hospital of Philadelphia ) Pediatric researchers investigating the childhood cancer neuroblastoma have identified common gene variants that raise the risk of an aggressive form of that disease. The discovery may assist doctors in better diagnosing subtypes of neuroblastoma.

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      Mentions: Genetics
    8. Cell surface protein may offer big target in treating high-risk childhood cancers

      Cell surface protein may offer big target in treating high-risk childhood cancers

      ( Children's Hospital of Philadelphia ) Oncology researchers studying high-risk children's cancers have identified a protein that offers a likely target for immunotherapy -- harnessing the immune system in medical treatments. In cell cultures and animal models, a potent drug attached to an antibody selectively zeroes in on cancer cells without harming healthy cells.

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    9. Seattle Children's opens CD22 CAR T-cell immunotherapy trial for children and young adults

      Seattle Children's opens CD22 CAR T-cell immunotherapy trial for children and young adults

      ( Seattle Children's ) After seeing promising results in phase 1 of the Pediatric Leukemia Adoptive Therapy (PLAT-02) trial with 93 percent of patients with relapsed or refractory acute lymphoblastic leukemia (ALL) achieving complete initial remission, researchers at Seattle Children's are continuing their quest to improve the experimental therapy and reduce the rate of relapse, which is about 50 percent.

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    10. Nanoparticles loaded with component of common spice kill cancer cells

      ( University of Central Florida ) Attaching curcumin, a component of the common spice turmeric, to nanoparticles can be used to target and destroy treatment-resistant neuroblastoma tumor cells, according to a new study published in Nanoscale. The study, conducted in partnership by researchers at Nemours Children's Hospital and the University of Central Florida, demonstrates a potentially novel treatment for neuroblastoma, the most common cancer in infants.

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    11. MRI without contrast agents? Yes, with sugar!

      MRI without contrast agents? Yes, with sugar!

      ( German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) ) Scientists from the German Cancer Research Center (DKFZ), in collaboration with colleagues from Heidelberg University Hospital, have been able to visualize brain cancer using a novel MRI method. They use a simple sugar solution instead of conventional contrast agents, which can have side effects in the body.

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      Mentions: Side Effects
    12. New biomarker assay detects neuroblastoma with greater sensitivity

      New biomarker assay detects neuroblastoma with greater sensitivity

      ( Children's Hospital Los Angeles ) Investigators at The Saban Research Institute of Children's Hospital Los Angeles have developed and tested a new biomarker assay for quantifying disease and detecting the presence of neuroblastoma even when standard evaluations yield negative results for the disease.

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      Mentions: NANT MIBG
    13. New research points to potential for more targeted treatments of neuroblastoma tumors

      New research points to potential for more targeted treatments of neuroblastoma tumors

      ( University of Chicago Medical Center ) Genetic variations appear to pre-dispose children to developing certain severe forms of neuroblastoma, according to new research by the University of Chicago Medicine. The findings lay the groundwork for developing more targeted treatments for particularly deadly variations of the cancer.

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      Mentions: MYCN
    14. Giving children a voice in clinical trials

      Giving children a voice in clinical trials

      ( Children's National Health System ) Children as young as 8 years old with incurable cancer can reliably characterize the impact an experimental therapy has on their symptoms and quality of life -- even at the earliest stages of drug development -- making self-reported patient outcomes a potential new clinical trial endpoint.

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    15. NCI-MATCH cancer trial reaches 6,000-patient tumor sequencing goal 2 years early

      NCI-MATCH cancer trial reaches 6,000-patient tumor sequencing goal 2 years early

      "The rapid pace of patient enrollment in the National Cancer Institute-Molecular Analysis for Therapy Choice (NCI-MATCH or EAY131) precision medicine cancer treatment trial will result in the study reaching its goal of sequencing the tumors of 6,000 patients in June, nearly two years sooner than expected. The ECOG-ACRIN Cancer Research Group (ECOG-ACRIN), which is leading this signal-finding trial under the sponsorship of the National Cancer Institute (NCI), reports that wide-scale adoption throughout the NCI National Clinical Trials Network (NCTN) and NCI Community Oncology Research Program (NCORP) caused the unprecedented rate of patient enrollment."

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    16. New assay shows promise to advance personalized therapy for cancer patients

      New assay shows promise to advance personalized therapy for cancer patients

      ( Elsevier Health Sciences ) The National Cancer Institute's NCI-MATCH (Molecular Analysis for Therapy Choice) is a large, ongoing clinical trial that matches tumors to therapies based on the tumor's genetic characteristics. A report in The Journal of Molecular Diagnostics confirms that the assay tailored for this trial is highly sensitive for detecting genetic mutations from a variety of tumor tissue and, for the first time, has been reproduced with accuracy by multiple clinical laboratories, laying the groundwork for future clinical utility.

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      Mentions: Diagnostics
    17. Parents of children with cancer value sequencing results, even if non-actionable

      "There is a general, ethical inclination to be reluctant to disclose sequencing information without clear clinical utility, especially when children are involved," said Dr. Malek, who presented the research. "However, our study showed that parents find this information useful in a much broader way than clinicians might expect," she said.  For example, many parents cited psychological benefits to receiving the information. "Almost all of the parents we interviewed wanted to know where the cancer had come from," Dr. Malek explained. "They hoped that evidence of a genetic cause would show that they had not caused it through any action or ...

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      Mentions: Genetics
    18. Loss of a microRNA family, let-7, found key in neuroblastoma

      Loss of a microRNA family, let-7, found key in neuroblastoma

      "The let-7 family of microRNAs (bits of genetic code that regulate genes) is known to be involved in both stem-cell differentiation and tumor suppression. Recent research had implicated LIN28B, a protein that inhibits let-7 maturation, in neuroblastoma. But the new study, through work on neuroblastoma cells and analysis of patient data, found that LIN28B is only one of several cancer mechanisms that involve let-7 suppression.  "We're showing that let-7 inhibition is central to the development of this disease," Powers says. "So critical in fact that neuroblastoma uses at least three distinct ways of eliminating it."  Powers and colleagues first ...

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      Mentions: MYCN Chemotherapy
    1-24 of 82 1 2 3 4 »
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