1. Articles in category: Regulation

    1-24 of 40 1 2 »
    1. Desogestrel DOWN-REGULATES PHOX2B And Its Target Genes In Progesterone Responsive Neuroblastoma Cells.

      DESOGESTREL DOWN-REGULATES PHOX2B AND ITS TARGET GENES IN PROGESTERONE RESPONSIVE NEUROBLASTOMA CELLS.

      Exp Cell Res. 2018 Jul 20;:

      Authors: Cardani S, Di Lascio S, Belperio D, Di Biase E, Ceccherini I, Benfante R, Fornasari D

      Abstract The paired-like homeobox 2B gene (PHOX2B) encodes a key transcription factor that plays a role in the development of the autonomic nervous system and the neural structures involved in controlling breathing.

      Read Full Article
      Mentions: PHOX2B
    2. Transcription factor activating protein 4 is synthetically lethal and a master regulator of MYCN-amplified neuroblastoma.

      Transcription factor activating protein 4 is synthetically lethal and a master regulator of MYCN-amplified neuroblastoma.

      Oncogene. 2018 Jun 07;:

      Authors: Boboila S, Lopez G, Yu J, Banerjee D, Kadenhe-Chiweshe A, Connolly EP, Kandel JJ, Rajbhandari P, Silva JM, Califano A, Yamashiro DJ

      Read Full Article
      Mentions: MYCN
    3. miR-129 inhibits tumor growth and potentiates chemosensitivity of neuroblastoma by targeting MYO10.

      miR-129 inhibits tumor growth and potentiates chemosensitivity of neuroblastoma by targeting MYO10.

      Biomed Pharmacother. 2018 Jul;103:1312-1318

      Authors: Wang X, Li J, Xu X, Zheng J, Li Q

      Abstract Although the treatment strategies for neuroblastoma (NB) develop rapidly, a considerable number of patients could not benefit from chemotherapy. Here, we revealed a miR-129-MYO10 axis that regulated neuroblastoma growth and chemosensitivity.

      Read Full Article
    4. MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma.

      MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma.

      Oncotarget. 2018 Apr 17;9(29):20323-20338

      Authors: Agarwal S, Milazzo G, Rajapakshe K, Bernardi R, Chen Z, Barberi E, Koster J, Perini G, Coarfa C, Shohet JM

      Abstract The MYC oncogenes and p53 have opposing yet interrelated roles in normal development and tumorigenesis. How MYCN expression alters the biology and clinical responsiveness of pediatric neuroblastoma remains poorly defined.

      Read Full Article
      Mentions: MYCN Tumorigenesis
    5. PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways.

      PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways.

      BMC Cancer. 2018 May 02;18(1):499

      Authors: Wu DD, Gao YR, Li T, Wang DY, Lu D, Liu SY, Hong Y, Ning HB, Liu JP, Shang J, Shi JF, Wei JS, Ji XY

      Read Full Article
    6. Targeting of epigenetic regulators in neuroblastoma.

      Targeting of epigenetic regulators in neuroblastoma.

      Exp Mol Med. 2018 Apr 27;50(4):51

      Authors: Jubierre L, Jiménez C, Rovira E, Soriano A, Sábado C, Gros L, Llort A, Hladun R, Roma J, Toledo JS, Gallego S, Segura MF

      Abstract Approximately 15,000 new cases of pediatric cancer are diagnosed yearly in Europe, with 8-10% corresponding to neuroblastoma, a rare disease with an incidence of 8-9 cases per million children <15 years of age.

      Read Full Article
    7. Chromatin Immunoprecipitation and DNA Sequencing Identified a LIMS1/ILK Pathway Regulated by LMO1 in Neuroblastoma.

      Chromatin Immunoprecipitation and DNA Sequencing Identified a LIMS1/ILK Pathway Regulated by LMO1 in Neuroblastoma.

      Cancer Genomics Proteomics. 2018 May-Jun;15(3):165-174

      Authors: Saeki N, Saito A, Sugaya Y, Amemiya M, Ono H, Komatsuzaki R, Yanagihara K, Sasaki H

      Read Full Article
      Mentions: Genetics
    8. BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma.

      BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma.

      Cell Death Dis. 2018 Apr 24;9(5):458

      Authors: Sime W, Niu Q, Abassi Y, Masoumi KC, Zarrizi R, Køhler JB, Kjellström S, Lasorsa VA, Capasso M, Fu H, Massoumi R

      Abstract BRCA1-associated protein 1 (BAP1) is a nuclear deubiquitinating enzyme that is associated with multiprotein complexes that regulate key cellular pathways, including cell cycle, cellular differentiation, cell death, and the DNA damage response.

      Read Full Article
    9. Inhibition of Sirtuin 6 Induces Neuroblastoma Differentiation.

      Inhibition of Sirtuin 6 Induces Neuroblastoma Differentiation.

      Anticancer Res. 2018 Feb;38(2):647-654

      Authors: Song HY, Rellinger EJ, Park SH, Paul P, Qiao J, Vasilopoulos A, Ozden O, Gius D, Chung DH

      Abstract BACKGROUND/AIM: Sirtuins (SIRTs) play crucial roles in various signaling pathways that modulate differentiation and proliferation. We sought to elucidate the role of SIRTs in differentiation and proliferation of human neuroblastoma (NB).

      Read Full Article
    10. 'Hijacker' drives cancer in some patients with high-risk neuroblastoma

      Researchers have identified mechanisms that drive about 10 percent of high-risk neuroblastoma cases and have used a new approach to show how the cancer genome “hijacks” DNA that regulates other genes. The resulting insights may help scientists develop more effective therapies, including ...

      Read Full Article
    11. Epigenetic regulation of neuroblastoma development.

      Epigenetic regulation of neuroblastoma development.

      Cell Tissue Res. 2018 Jan 19;:

      Authors: Kaat D, Frank S

      Abstract In recent years, technological advances have enabled a detailed landscaping of the epigenome and the mechanisms of epigenetic regulation that drive normal cell function, development and cancer.

      Read Full Article
    12. Delay in reforming European rules could deny thousands of children access to latest cancer drugs

      Thousands of children with cancer across Europe could miss out on the latest targeted treatments because of delays reforming outdated regulations, leading cancer research institutions, charities and expert bodies are warning.

      The European Commission has...

      Read Full Article
    13. TNF-α and IFN-γ Together Up-Regulates Par-4 Expression and Induce Apoptosis in Human Neuroblastomas.

      TNF-α and IFN-γ Together Up-Regulates Par-4 Expression and Induce Apoptosis in Human Neuroblastomas.

      Biomedicines. 2017 Dec 26;6(1):

      Authors: Shelke GV, Jagtap JC, Kim DK, Shah RD, Das G, Shivayogi M, Pujari R, Shastry P

      Abstract The objective of this study was to examine the combined effect of Interferon-gamma (IFN-γ) and Tumor Necrosis factor-alpha (TNF-α) on cytotoxicity and expression of prostate apoptosis response-4 (Par-4) and Par-4 interacting proteins B-cell lymphoma (Bcl-2), nuclear factor kappa-light-chain-enhancer of activated B cells/p65 subunit (NF-κB/p65), Ak mouse strain thymoma (Akt) in human neuroblastoma (NB) cells. Materials and methods included human neuroblastoma cell ...

      Read Full Article
      Mentions: Treatment
    14. Delay in reforming European rules could deny thousands of children access to latest cancer drugs

      Delay in reforming European rules could deny thousands of children access to latest cancer drugs

      Thousands of children with cancer across Europe could miss out on the latest targeted treatments because of delays reforming outdated regulations, leading cancer research institutions, charities and expert bodies are warning.

      Read Full Article
    15. Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle.

      Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle.

      Cell Rep. 2017 Dec 19;21(12):3483-3497

      Authors: Büchel G, Carstensen A, Mak KY, Roeschert I, Leen E, Sumara O, Hofstetter J, Herold S, Kalb J, Baluapuri A, Poon E, Kwok C, Chesler L, Maric HM, Rickman DS, Wolf E, Bayliss R, Walz S, Eilers M

      Read Full Article
    16. Tumor-associated macrophages promote neuroblastoma via STAT3 phosphorylation and up-regulation of c-MYC.

      Tumor-associated macrophages promote neuroblastoma via STAT3 phosphorylation and up-regulation of c-MYC.

      Oncotarget. 2017 Oct 31;8(53):91516-91529

      Authors: Hadjidaniel MD, Muthugounder S, Hung LT, Sheard MA, Shirinbak S, Chan RY, Nakata R, Borriello L, Malvar J, Kennedy RJ, Iwakura H, Akamizu T, Sposto R, Shimada H, DeClerck YA, Asgharzadeh S

      Read Full Article
      Mentions: MYCN
    17. Lin28B and miR-142-3p regulate neuronal differentiation by modulating Staufen1 expression.

      Lin28B and miR-142-3p regulate neuronal differentiation by modulating Staufen1 expression.

      Cell Death Differ. 2017 Nov 03;:

      Authors: Oh Y, Park J, Kim JI, Chang MY, Lee SH, Cho YH, Hwang J

      Abstract Staufen1 (STAU1) and Lin28B are RNA-binding proteins that are involved in neuronal differentiation as a function of post-transcriptional regulation. STAU1 triggers post-transcriptional regulation, including mRNA export, mRNA relocation, translation and mRNA decay.

      Read Full Article
    18. MYCN-targeting vaccines and immunotherapeutics.

      MYCN-targeting vaccines and immunotherapeutics.

      Hum Vaccin Immunother. 2016 Sep;12(9):2257-8

      Authors: Schramm A, Lode H

      Abstract Amplification and concomitant overexpression of the MYCN oncogene is a frequent event in many malignancies including the childhood tumors, neuroblastoma and medulloblastoma. MYCN is only expressed in a defined time frame during early developmental processes, (1) which is beneficial for approaches combatting tumor-specific MYCN.

      Read Full Article
      Mentions: MYCN
    19. CDDO and ATRA Instigate Differentiation of IMR32 Human Neuroblastoma Cells.

      CDDO and ATRA Instigate Differentiation of IMR32 Human Neuroblastoma Cells.

      Front Mol Neurosci. 2017;10:310

      Authors: Chaudhari N, Talwar P, Lefebvre D'hellencourt C, Ravanan P

      Abstract Neuroblastoma is the most common solid extra cranial tumor in infants. Improving the clinical outcome of children with aggressive tumors undergoing one of the multiple treatment options has been a major concern.

      Read Full Article
      Mentions: Treatment ALK MYCN
    20. Incorporating genomic, transcriptomic and clinical data: a prognostic and stem cell-like MYC and PRC imbalance in high-risk neuroblastoma.

      Incorporating genomic, transcriptomic and clinical data: a prognostic and stem cell-like MYC and PRC imbalance in high-risk neuroblastoma.

      BMC Syst Biol. 2017 Oct 03;11(Suppl 5):92

      Authors: Yang XH, Tang F, Shin J, Cunningham JM

      Abstract BACKGROUND: Previous studies suggested that cancer cells possess traits reminiscent of the biological mechanisms ascribed to normal embryonic stem cells (ESCs) regulated by MYC and Polycomb repressive complex 2 (PRC2).

      Read Full Article
      Mentions: MYCN
    21. Neuroblastoma cells undergo transcriptomic alterations upon dissemination into the bone marrow and subsequent tumor progression.

      Neuroblastoma cells undergo transcriptomic alterations upon dissemination into the bone marrow and subsequent tumor progression.

      Int J Cancer. 2017 Sep 16;:

      Authors: Rifatbegovic F, Frech C, Abbasi MR, Taschner-Mandl S, Weiss T, Schmidt WM, Schmidt I, Ladenstein R, Ambros IM, Ambros PF

      Read Full Article
      Mentions: Bone Marrow
    22. Annexin A2 could enhance multidrug resistance by regulating NF-κB signaling pathway in pediatric neuroblastoma.

      Annexin A2 could enhance multidrug resistance by regulating NF-κB signaling pathway in pediatric neuroblastoma.

      J Exp Clin Cancer Res. 2017 Aug 16;36(1):111

      Authors: Wang Y, Chen K, Cai Y, Cai Y, Yuan X, Wang L, Wu Z, Wu Y

      Abstract BACKGROUND: Chemotherapy is one of major therapeutic regimens for neuroblastoma (NB) in children. However, recurrence and metastasis associated with poor prognosis caused by acquired multidrug resistance remains a challenge.

      Read Full Article
    1-24 of 40 1 2 »
  1. Categories

    1. Research:

      Cancer Cell, Case Report, Cells and Stem Cells, Clinical Research, Conferences, Disease Classification, Drug, Drug Delivery, Drug Resistance, Epigenetics and Epigenomics, General, Genetics, Genomics, Guidelines, Immune Therapy, Induction, Long Term Effects, Low / Intermediate Risk, Nanotechnology, Olfactory Neuroblastoma, Onco-Fertility, Oncogenesis, Other Cancers, Personalized Medicine, Pharma, Pre-Clinical, Prognostics, PubMed, Review, Small Molecules, Surgery, Survivorship, Trials, Tumor Biology, Virotherapy
    2. Business:

      Funding, IP, Pharma
    3. Non-Profit:

      Advocacy, Charity, Events, Foundation, Funding, Human Interest
    4. Press Release:

      Announcement, News, Pharma
    5. General:

      Adolescent and Young Adults, Bioethics, Blog, Burden of Treatment, Children & Families, Diagnosis and Detection, Drug Development, Epidemiology, Imaging, Incidence, Information, News, Overview of the Disease, Pain Control, Palliative Care, Psychosocial, Regulation, Side-Effects, Social, Supportive Care, Treatment
    6. Media:

      Audio, Blogs, Video
  2. Popular Articles