1. Articles in category: Other Cancers

    1-24 of 180 1 2 3 4 5 6 7 8 »
    1. Nanoparticles give immune cells a boost

      Nanoparticles give immune cells a boost

      ( Massachusetts Institute of Technology ) MIT researchers have devised a novel way to boost the effectiveness of T cell therapy against solid tumors. By attaching nanoparticle 'backpacks' carrying immune-stimulating drugs directly to T cells, the MIT engineers showed that they could enhance those T cells' response without inducing harmful side effects.

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    2. Nanoparticles That Reshape the Tumor Milieu Create a Therapeutic Window for Effective T-cell Therapy in Solid Malignancies

      Nanoparticles That Reshape the Tumor Milieu Create a Therapeutic Window for Effective T-cell Therapy in Solid Malignancies

      A major obstacle to the success rate of chimeric antigen receptor (CAR-) T-cell therapy against solid tumors is the microenvironment antagonistic to T cells that solid tumors create. Conventional checkpoint blockade can silence lymphocyte antisurvival pathways activated by tumors, but because they are systemic, these treatments disrupt immune homeostasis and induce autoimmune side effects. Thus, new technologies are required to remodel the tumor milieu without causing systemic toxicities.

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    3. Burkholderia Lethal Factor 1, a Novel Anti-Cancer Toxin, Demonstrates Selective Cytotoxicity in MYCN-Amplified Neuroblastoma Cells.

      Burkholderia Lethal Factor 1, a Novel Anti-Cancer Toxin, Demonstrates Selective Cytotoxicity in MYCN-Amplified Neuroblastoma Cells.

      Toxins (Basel). 2018 Jun 27;10(7):

      Authors: Rust A, Shah S, Hautbergue GM, Davletov B

      Abstract Immunotoxins are being investigated as anti-cancer therapies and consist of a cytotoxic enzyme fused to a cancer targeting antibody.

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      Mentions: Antibody MYCN
    4. Pediatric Cancer Immunotherapy: Opportunities and Challenges.

      Pediatric Cancer Immunotherapy: Opportunities and Challenges.

      Paediatr Drugs. 2018 Jun 12;:

      Authors: Wedekind MF, Denton NL, Chen CY, Cripe TP

      Abstract Cancer immunotherapies, widely heralded as transformational for many adult cancer patients, are becoming viable options for selected subsets of pediatric cancer patients.

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      Mentions: Immunotherapy
    5. New method to preserve boy cancer patient fertility being developed

      New method to preserve boy cancer patient fertility being developed

      Ben-Gurion University of the Negev (BGU) and Soroka University Medical Center researchers in Beer-Sheva, Israel are developing a cell culture system that for the first time can change testicular stem cells into sperm-like cells that may enable future fertility for boys with prepubertal cancer.

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      Mentions: Genetics
    6. Network Modeling of microRNA-mRNA Interactions in Neuroblastoma Tumorigenesis Identifies miR-204 as a Direct Inhibitor of MYCN

      Network Modeling of microRNA-mRNA Interactions in Neuroblastoma Tumorigenesis Identifies miR-204 as a Direct Inhibitor of MYCN

      Neuroblastoma is a pediatric cancer of the sympathetic nervous system where MYCN amplification is a key indicator of poor prognosis. However, mechanisms by which MYCN promotes neuroblastoma tumorigenesis are not fully understood. In this study, we analyzed global miRNA and mRNA expression profiles of tissues at different stages of tumorigenesis from TH-MYCN transgenic mice, a model of MYCN-driven neuroblastoma.

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      Mentions: Imaging MYCN Genetics
    7. CureWorks Collaborative Launches to Accelerate Development of Immunotherapy Treatments for Childhood Cancers, Increase Access to Clinical Trials

      Seattle Children's, with participating members Children's National Health System, BC Children's Hospital and Children's Hospital Los Angeles, has launched CureWorks, an international collaborative of leading academic children's hospitals determined to accelerate the development of immunotherapy treatments for childhood cancer. CureWorks focuses on expanding immunotherapy trials and patient access around the world, as well as sharing data and collective expertise to advance novel cell therapies.

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      Mentions: Immunotherapy
    8. President Signs STAR Act for Kids' Cancers.

      President Signs STAR Act for Kids' Cancers.

      Cancer Discov. 2018 Jun 07;:

      Authors:

      Abstract On June 5, President Donald Trump signed the Childhood Cancer Survivorship, Treatment, Access and Research Act, which aims to support pediatric cancer research by expanding the collection of patient biospecimens and records, improving surveillance, and investigating pediatric survivorship.

      PMID: 29880581 [PubMed - as supplied by publisher]

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      Mentions: Treatment
    9. Erythropoietin enhances migration of human neuroblastoma cells: in vitro studies and potential therapeutic implications.

      Erythropoietin enhances migration of human neuroblastoma cells: in vitro studies and potential therapeutic implications.

      J Cancer Stem Cell Res. 2017;5:

      Authors: Poniewierska-Baran A, Rajewska-Majchrzak J, Ratajczak MZ

      Abstract The erythropoietin receptor (EpoR) is expressed by cells from the erythroid lineage; however, evidence has accumulated that it is also expressed by some other non-hematopoietic tissues including several solid tumor cells and proposed candidates for cancer stem cells. This is an important concern, because recombinant erythropoietin (EPO) is frequently employed in cancer patients as a drug to ameliorate anemia related to chemo/radiotherapy. In our studies, we employed three human neuroblastoma ...

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      Mentions: Radiotherapy
    10. Rigorous study finds widely used treatment for infection fails young cancer patients

      A treatment designed to reduce bloodstream infections due to central venous catheters that had worked well in lab studies and is commonly used around the world, but had not been rigorously tested, failed to protect young cancer patients from recurring or...

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      Mentions: Treatment
    11. Rigorous study finds widely used treatment for infection fails young cancer patients

      Rigorous study finds widely used treatment for infection fails young cancer patients

      ( St. Jude Children's Research Hospital ) St. Jude Children's Research Hospital found ethanol-lock therapy failed to prevent new or recurring infections in cancer patients with central venous catheters and was associated with increased complications.

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      Mentions: Treatment
    12. NCI-MATCH precision medicine clinical trial releases new findings, strengthens path forward for targeted cancer therapies

      NCI-MATCH precision medicine clinical trial releases new findings, strengthens path forward for targeted cancer therapies

      The NCI-MATCH precision medicine clinical trial has reached a milestone with the release of results from several study treatment arms. Findings from three arms were released at the 2018 ASCO annual meeting, adding to findings from one arm released in 2017.

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    13. Childhood cancer: The four survival strategies of tumor cells

      Childhood cancer: The four survival strategies of tumor cells

      ( Lund University ) Cancer cells in children tend to develop by following four main trajectories -- and two of them are linked to relapse of the disease, research led by Lund University in Sweden shows. The four strategies can occur simultaneously in a single tumor, according to the study that is now published in Nature Genetics.

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      Mentions: Relapse Genetics
    14. Tune Up In Situ Autovaccination against Solid Tumors with Oncolytic Viruses.

      Tune Up In Situ Autovaccination against Solid Tumors with Oncolytic Viruses.

      Cancers (Basel). 2018 May 31;10(6):

      Authors: Nguyen T, Avci NG, Shin DH, Martinez-Velez N, Jiang H

      Abstract With the progress of immunotherapy in cancer, oncolytic viruses (OVs) have attracted more and more attention during the past decade.

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    15. How Might Baking Soda Boost Cancer Therapy?

      How Might Baking Soda Boost Cancer Therapy?

      A Ludwig Cancer Research study has uncovered an entirely novel mechanism by which cells enter a state of dormancy as tissues starved of oxygen become increasingly acidic. The study, led by Chi Van Dang, scientific director of the Ludwig Institute for Cancer Research, has potentially significant implications for cancer therapy: Large swaths of solid tumors are often deprived of oxygen, and cells in such patches are thought to be a major source of drug resistance and disease relapses.

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      Mentions: Immunotherapy
    16. Anti-inflammatory strategy could lead to improved survival of children with neuroblastoma

      Anti-inflammatory strategy could lead to improved survival of children with neuroblastoma

      Download PDF Copy May 28, 2018 Researchers at Karolinska Institutet and Karolinska University Hospital have discovered that an anti-inflammatory drug candidate inhibiting the prostaglandin E2 producing enzyme mPGES-1 in the tumor stroma reduces tumor growth in experimental neuroblastoma models. The findings are published in EBioMedicine and open for new treatment strategies for this aggressive childhood cancer. "High-risk neuroblastoma is the most common and deadly cancer in infants.

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      Mentions: Treatment
    1-24 of 180 1 2 3 4 5 6 7 8 »
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