1. Articles in category: Pharma

    1-8 of 8
    1. An Ethical Framework for Allocating Scarce Life-Saving Chemotherapy and Supportive Care Drugs for Childhood Cancer.

      "The ethical framework proposed in this Commentary is based upon multidisciplinary expert opinion, further strengthened by an independent panel of peer consultants. The two-step allocation process includes strategies to mitigate existing shortages by minimizing waste and addresses actual prioritization across and within diseases according to a modified utilitarian model that maximizes total benefit while respecting limited constraints on differential treatment of individuals. The framework provides reasoning for explicit decision-making in the face of an actual drug shortage. Moreover, it minimizes bias that might occur when individual clinicians or institutions are forced to make bedside rationing and prioritization decisions and addresses ...

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      Mentions: Chemotherapy
    2. Leading Pediatric Oncologist Group Releases Guidance for Rationing Childhood Cancer Drugs in Anticipation of Future Drug Shortages

      "Our intention with this project was to try to help the childhood cancer community manage the crisis that will occur when, not if, the next drug shortage happens," said COG Chairman Dr. Peter Adamson. "This is a problem almost exclusively impacting children in the United States and not other developed countries. The problem should be preventable, but will require the government to take additional steps to address the fundamental causes of these shortages. Until further action is taken, we are doing everything in our power to help prepare for the next shortage when pediatric oncologists may be forced into rationing ...

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      Mentions: COG Chemotherapy
    3. Intravenous nutrition source could reduce side effects of chemotherapy

      PITTSBURGH -- A single dose of an FDA-approved intravenous nutrition source may be able to significantly reduce the toxicity and increase the bioavailability of platinum-based cancer drugs, according to a study by Carnegie Mellon University biologists published in Scientific Reports. Platinum-based drugs, including cisplatin, carboplatin and oxyplatin, have been used to treat cancer for more than 35 years.

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      Mentions: Side Effects
    4. FDA priority review for Opdivo/Yervoy combo in skin cancer

      US regulators have agreed to review a supplemental filing for Bristol-Myers Squibb’s combination of immunotherapies Opdivo and Yervoy in patients with previously untreated advanced melanoma. The US Food and Drug Administration has assigned the application a priority review, on the back of data (from CheckMate-069) showing that the Opdivo (nivolumab)/Yervoy (ipilimumab) regimen achieved tumour shrinkage in 61% of patients and a complete response in 22%.

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      Mentions: PD-1
    1-8 of 8
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