1. Articles in category: Imaging

    1-25 of 25
    1. Evaluation of the utility of 99mTc-MDP bone scintigraphy versus MIBG scintigraphy and cross-sectional imaging for staging patients with neuroblastoma

      Accurate staging of neuroblastoma requires multiple imaging examinations. The purpose of this study was to determine the relative contribution of 99mTc-methylene diphosphonate (MDP) bone scintigraphy (bone scan) versus metaiodobenzylguanidine scintigraphy (MIBG scan) for accurate staging of neuroblastoma.

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      Mentions: Staging Imaging MIBG
    2. Neuroblastoma: MIBG Imaging and New Tracers.

      Neuroblastoma: MIBG Imaging and New Tracers.

      Semin Nucl Med. 2017 Mar;47(2):143-157

      Authors: Pfluger T, Piccardo A

      Abstract Neuroblastoma is an embryonic tumor of the peripheral sympathetic nervous system, and is metastatic or otherwise high risk for relapse in nearly 50% of cases, with a long-term survival of <40%. Therefore, exact staging with radiological and nuclear medicine imaging methods is crucial for finding the adequate therapeutic choice.

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    3. Image-defined risk factors for nephrectomy in patients undergoing neuroblastoma resection.

      "Encasement and narrowing of renal vessels, delayed excretion, and tumor invasion into the kidney, particularly pelvis and capsule invasion, are significantly associated with partial or total nephrectomy at initial neuroblastoma resection. These observations provide valuable information for surgical planning as well as presurgical discussions with families prior to neuroblastoma resection."

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    4. MIBG in Neuroblastoma Diagnostic Imaging and Therapy.

      MIBG in Neuroblastoma Diagnostic Imaging and Therapy.

      Radiographics. 2016 Jan-Feb;36(1):258-278

      Authors: Sharp SE, Trout AT, Weiss BD, Gelfand MJ

      Abstract Neuroblastoma is a common malignancy observed in infants and young children. It has a varied prognosis, ranging from spontaneous regression to aggressive metastatic tumors with fatal outcomes despite multimodality therapy. Patients are divided into risk groups on the basis of age, stage, and biologic tumor factors.

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    5. A Novel Method for Assessment of Natural Killer Cell Cytotoxicity Using Image Cytometry.

      A Novel Method for Assessment of Natural Killer Cell Cytotoxicity Using Image Cytometry.

      PLoS One. 2015;10(10):e0141074

      Authors: Somanchi SS, McCulley KJ, Somanchi A, Chan LL, Lee DA

      Abstract Natural killer (NK) cells belong to the innate arm of the immune system and though activated NK cells can modulate immune responses through the secretion of cytokines, their primary effector function is through target cell lysis.

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      Mentions: NK Cells Imaging
    6. Tumor lysing genetically engineered T cells loaded with multi-modal imaging agents.

      Tumor lysing genetically engineered T cells loaded with multi-modal imaging agents.

      Tumor lysing genetically engineered T cells loaded with multi-modal imaging agents.

      Sci Rep. 2014;4:4502

      Authors: Bhatnagar P, Alauddin M, Bankson JA, Kirui D, Seifi P, Huls H, Lee DA, Babakhani A, Ferrari M, Li KC, Cooper LJ

      Abstract Genetically-modified T cells expressing chimeric antigen receptors (CAR) exert anti-tumor effect by identifying tumor-associated antigen (TAA), independent of major histocompatibility complex.

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      Mentions: T-Cells Imaging
    7. Preoperative surgical simulation of laparoscopic adrenalectomy for neuroblastoma using a three-dimensional printed model based on preoperative CT images.

      "The multi-detector CT images were transferred to a 3D workstation, and 3D volume data were obtained by reconstructing the sections. A model was made with a 3D printer using acrylic ultraviolet curable resin. The adrenal tumor, kidney, renal vein and artery, inferior vena cava, aorta, and outer body were fabricated. The pneumoperitoneum, insertion of trocars, and laparoscopic view were all attainable in this model. We used this model for three cases with adrenal NB.  We used this model to discuss the port layout before the operation and to simulate the laparoscopic view and range of forceps movement. All three cases ...

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    8. 123I-MIBG scintigraphy and 18F-FDG-PET imaging for diagnosing neuroblastoma.

      123I-MIBG scintigraphy and 18F-FDG-PET imaging for diagnosing neuroblastoma.

      Cochrane Database Syst Rev. 2015 Sep 29;9:CD009263

      Authors: Bleeker G, Tytgat GA, Adam JA, Caron HN, Kremer LC, Hooft L, van Dalen EC

      Abstract BACKGROUND: Neuroblastoma is an embryonic tumour of childhood that originates in the neural crest.

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      Mentions: Imaging MIBG
    9. New Test Shows Effectiveness of Cancer Therapy in Children

      "An important benefit of CEUS imaging is that it allows us to quantify blood flow and determine if tumors are responding to the blood vessel targeting chemotherapy, whereas the conventional method of assessing these tumors with CT and MR evaluates only changes in tumor size. The St Jude investigators found that CEUS measurements predicted which patients would respond to therapy at very early time points. The results were announced today at the annual International Contrast Ultrasound Society (ICUS) conference in Chicago."

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      Mentions: Imaging
    10. Usefulness of positron emission tomography in the differentiation between tumor and infectious lesions in pediatric oncology: a case report.

      Usefulness of positron emission tomography in the differentiation between tumor and infectious lesions in pediatric oncology: a case report.

      BMC Pediatr. 2015;15(1):108

      Authors: Tibúrcio FR, de Sá Rodrigues KE, Vasconcelos HM, Miranda DM, Simões E Silva AC

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      Mentions: Imaging
    11. Initial Experience With Gallium-68 DOTA-Octreotate PET/CT and Peptide Receptor Radionuclide Therapy for Pediatric Patients With Refractory Metastatic Neuroblastoma.

      "GaTATE PET was positive in a high proportion of patients with refractory neuroblastoma, correlating with SSTR 2 on IHC, with additional disease identified compared with MIBG imaging. PRRT seems safe, feasible, with responses observed in patients with progression despite multimodality treatment. These data support ongoing clinical trials in such patients."

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    12. MRI Scanners Can Steer Tumor Busting Viruses to Specific Target Sites Within the Body

      "An international team of researchers, led by Dr Munitta Muthana from the University of Sheffield's Department of Oncology, have now found MRI scanners can non-invasively steer cells, which have been injected with tiny super-paramagnetic iron oxide nanoparticles (SPIOs), to both primary and secondary tumour sites within the body.  This targeted approach is extremely beneficial for patients as it dramatically increases the efficiency of treatment and drug doses could potentially be reduced - helping to alleviate side effects."

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      Mentions: Staging Imaging
    13. PD-L1 Imaging

      "Antibodies that block the interaction between programmed death ligand 1 (PD-L1) and PD-1 have shown impressive antitumor activity. Patients with tumors expressing PD-L1 are most likely to respond to this treatment. The aim of our study was to develop a noninvasive imaging technique to determine tumor PD-L1 expression in vivo. This could allow selection of patients that are most likely to benefit from anti–PD-1/PD-L1 treatment and to monitor PD-L1 expression during therapy. The monoclonal antibody PD-L1.3.1 was radiolabeled with Indium-111 (111In) and characterized using PD-L1–expressing MDA-MB-231 cells."

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    14. De Novo Assessment of Pediatric Musculoskeletal Soft Tissue Tumors: Beyond Anatomic Imaging.

      1The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Medical Institutions, Baltimore, Maryland sahlawa1@jhmi.edu. 2The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Medical Institutions, Baltimore, Maryland. MRI plays a central role in the assessment of pediatric musculoskeletal soft tissue tumors.

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      Mentions: Imaging
    15. Whole-Body Pediatric Neuroblastoma Imaging: 123I-mIBG and Beyond.

      "Pediatric cancer imaging stands to benefit from higher tumor detection sensitivity without ionizing radiation exposure. A prospective protocol compared diagnostic I-metaiodobenzylguanidine (I-mIBG) with whole-body diffusion-weighted MRI (DWI) to validate adjunctive methods of identifying small-volume oligometastatic neuroblastoma tumor deposits. Dual-modality imaging (I-mIBG and DWI) was obtained within a 3- and 25-day window at baseline and again at one year in the first enrolled patient. MRI was able to define the full extent of metastatic disease foci with improved resolution. These findings may provide critical information for definitive locoregional surgery and radiotherapy for high-risk neuroblastoma treatment."

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      Mentions: Imaging MIBG
    16. [18 F]-6-L-fluorodihydroxyphenylalanine (18F-FDOPA) Positron Emission Tomography (PET) in Neuroendocrine Tumours

      Conditions :   Thyroid Cancer, Medullary;   Carcinoid Tumor;   Pheochromocytoma;   Paraganglioma;   Insulinoma;   Neuroblastoma Intervention :   Drug: [18 F]-6-L-fluorodihydroxyphenylalanine (18F-FDOPA) Sponsor :   British Columbia Cancer Agency Available - verified April 2015

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      Mentions: Imaging
    17. Imaging immunity

      "For the current research, the lab generated VHHs that recognize mouse immune cells, then labeled these VHHs with radioisotopes, and injected them into tumor-bearing mice. Subsequent PET imaging detected the location of immune cells around the tumor quickly and accurately.  "We were able to image tumors as small as one millimeter in size and within just a few days of their starting to grow," says Mohammad Rashidian, a postdoctoral researcher in Ploegh's lab and first author of the PNAS paper. "We're very excited about this because it's a powerful approach to pick up inflammation in and around ...

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      Mentions: Imaging
    18. Neuroblastoma and nephroblastoma: a radiological review.

      Neuroblastoma and nephroblastoma: a radiological review.

      "Oncogenetics and chromosomal abnormalities are increasingly recognised as important prognostic indicators and their impact on initial management is considered. Imaging plays a pivotal role in terms of diagnosis and recent imaging advances mean that radiology has an increasingly crucial role in the management pathway. The use of image defined risk factors in neuroblastoma has begun to dramatically change how this tumour is characterised pre-operatively."

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      Mentions: Imaging
    19. Review Article ~ Advances in Neuroblastoma

      Review Article ~ Advances in Neuroblastoma

      June 2010 review by Dr John Maris in the New England Journal of Medicine (click on image for full-text, posted with permission at CNCFhope.org):

      You can also follow the link below to view a 24 minute webcast of an April 2010 AACR meeting presented by John Maris: “Bridging the Gap: Moving Laboratory Discoveries into Clinical Trials”.
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    1-25 of 25
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