1. Articles in category: Imaging

    1-24 of 31 1 2 »
    1. Composite iron oxide-Prussian blue nanoparticles for magnetically guided T1-weighted magnetic resonance imaging and photothermal therapy of tumors.

      Composite iron oxide-Prussian blue nanoparticles for magnetically guided T1-weighted magnetic resonance imaging and photothermal therapy of tumors.

      Int J Nanomedicine. 2017;12:6413-6424

      Authors: Kale SS, Burga RA, Sweeney EE, Zun Z, Sze RW, Tuesca A, Subramony JA, Fernandes R

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    2. Assessment of Organ Dosimetry for Planning Repeat Treatments of High-Dose 131I-MIBG Therapy: 123I-MIBG Versus Posttherapy 131I-MIBG Imaging.

      Assessment of Organ Dosimetry for Planning Repeat Treatments of High-Dose 131I-MIBG Therapy: 123I-MIBG Versus Posttherapy 131I-MIBG Imaging.

      Clin Nucl Med. 2017 Jul 29;:

      Authors: Pandit-Taskar N, Zanzonico P, Hilden P, Ostrovnaya I, Carrasquillo JA, Modak S

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    3. Biodistribution and dosimetry of (18)F-Meta Fluorobenzyl Guanidine (MFBG): A first-in-human PET-CT imaging study of patients with neuroendocrine malignancies.

      Biodistribution and dosimetry of (18)F-Meta Fluorobenzyl Guanidine (MFBG): A first-in-human PET-CT imaging study of patients with neuroendocrine malignancies.

      J Nucl Med. 2017 Jul 13;:

      Authors: Pandit-Taskar N, Zanzonico PB, Staton KD, Carrasquillo JA, Reidy-Lagunes D, Lyashchenko SK, Burnazi E, Zhang H, Lewis JS, Blasberg R, Larson SM, Weber WA, Modak S

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      Mentions: Imaging MIBG
    4. Metastatic Neuroblastoma in Adult Patient, Presenting as a Super Scan on 68Ga-DOTANOC PET/CT Imaging.

      Metastatic Neuroblastoma in Adult Patient, Presenting as a Super Scan on 68Ga-DOTANOC PET/CT Imaging.

      Clin Nucl Med. 2017 Jul 06;:

      Authors: Malik D, Jois A, Singh H, Bora GS, Basher RK, Mittal BR

      Abstract We report a case of 23-year-old man who presented with complaints of progressive abdominal distension for the past 3 months along with the loss of appetite and weight and had a large solid cystic mass in the left half of the abdominal cavity revealed on ultrasonography and contrast-enhanced CT of the abdomen. Subsequent biopsy and histopathology revealed it to be neuroblastoma. Ga-DOTANOC PET/CT scan ...

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      Mentions: Imaging Biopsy
    5. Neuroblastoma Presenting as Non-MIBG-Avid Widespread Soft Tissue Metastases Without Bone Involvement Revealed by Fdg PET/CT Imaging.

      Neuroblastoma Presenting as Non-MIBG-Avid Widespread Soft Tissue Metastases Without Bone Involvement Revealed by FDG PET/CT Imaging.

      Clin Nucl Med. 2017 May 19;:

      Authors: Tolboom N, Servaes SE, Zhuang H

      Abstract Soft tissue metastases from neuroblastoma very rarely occur without concurrent osseous metastases. We report 1 case of non-MIBG-avid, high-risk neuroblastoma in a pediatric patient who had widespread soft tissue metastases without concurrent osseous lesion on FDG PET/CT imaging.

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      Mentions: Imaging MIBG
    6. Evaluation of the utility of 99mTc-MDP bone scintigraphy versus MIBG scintigraphy and cross-sectional imaging for staging patients with neuroblastoma

      Accurate staging of neuroblastoma requires multiple imaging examinations. The purpose of this study was to determine the relative contribution of 99mTc-methylene diphosphonate (MDP) bone scintigraphy (bone scan) versus metaiodobenzylguanidine scintigraphy (MIBG scan) for accurate staging of neuroblastoma.

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      Mentions: Staging Imaging MIBG
    7. Neuroblastoma: MIBG Imaging and New Tracers.

      Neuroblastoma: MIBG Imaging and New Tracers.

      Semin Nucl Med. 2017 Mar;47(2):143-157

      Authors: Pfluger T, Piccardo A

      Abstract Neuroblastoma is an embryonic tumor of the peripheral sympathetic nervous system, and is metastatic or otherwise high risk for relapse in nearly 50% of cases, with a long-term survival of <40%. Therefore, exact staging with radiological and nuclear medicine imaging methods is crucial for finding the adequate therapeutic choice.

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    8. Image-defined risk factors for nephrectomy in patients undergoing neuroblastoma resection.

      "Encasement and narrowing of renal vessels, delayed excretion, and tumor invasion into the kidney, particularly pelvis and capsule invasion, are significantly associated with partial or total nephrectomy at initial neuroblastoma resection. These observations provide valuable information for surgical planning as well as presurgical discussions with families prior to neuroblastoma resection."

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    9. MIBG in Neuroblastoma Diagnostic Imaging and Therapy.

      MIBG in Neuroblastoma Diagnostic Imaging and Therapy.

      Radiographics. 2016 Jan-Feb;36(1):258-278

      Authors: Sharp SE, Trout AT, Weiss BD, Gelfand MJ

      Abstract Neuroblastoma is a common malignancy observed in infants and young children. It has a varied prognosis, ranging from spontaneous regression to aggressive metastatic tumors with fatal outcomes despite multimodality therapy. Patients are divided into risk groups on the basis of age, stage, and biologic tumor factors.

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    10. A Novel Method for Assessment of Natural Killer Cell Cytotoxicity Using Image Cytometry.

      A Novel Method for Assessment of Natural Killer Cell Cytotoxicity Using Image Cytometry.

      PLoS One. 2015;10(10):e0141074

      Authors: Somanchi SS, McCulley KJ, Somanchi A, Chan LL, Lee DA

      Abstract Natural killer (NK) cells belong to the innate arm of the immune system and though activated NK cells can modulate immune responses through the secretion of cytokines, their primary effector function is through target cell lysis.

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      Mentions: NK Cells Imaging
    11. Tumor lysing genetically engineered T cells loaded with multi-modal imaging agents.

      Tumor lysing genetically engineered T cells loaded with multi-modal imaging agents.

      Tumor lysing genetically engineered T cells loaded with multi-modal imaging agents.

      Sci Rep. 2014;4:4502

      Authors: Bhatnagar P, Alauddin M, Bankson JA, Kirui D, Seifi P, Huls H, Lee DA, Babakhani A, Ferrari M, Li KC, Cooper LJ

      Abstract Genetically-modified T cells expressing chimeric antigen receptors (CAR) exert anti-tumor effect by identifying tumor-associated antigen (TAA), independent of major histocompatibility complex.

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      Mentions: T-Cells Imaging
    12. Preoperative surgical simulation of laparoscopic adrenalectomy for neuroblastoma using a three-dimensional printed model based on preoperative CT images.

      "The multi-detector CT images were transferred to a 3D workstation, and 3D volume data were obtained by reconstructing the sections. A model was made with a 3D printer using acrylic ultraviolet curable resin. The adrenal tumor, kidney, renal vein and artery, inferior vena cava, aorta, and outer body were fabricated. The pneumoperitoneum, insertion of trocars, and laparoscopic view were all attainable in this model. We used this model for three cases with adrenal NB.  We used this model to discuss the port layout before the operation and to simulate the laparoscopic view and range of forceps movement. All three cases ...

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    13. 123I-MIBG scintigraphy and 18F-FDG-PET imaging for diagnosing neuroblastoma.

      123I-MIBG scintigraphy and 18F-FDG-PET imaging for diagnosing neuroblastoma.

      Cochrane Database Syst Rev. 2015 Sep 29;9:CD009263

      Authors: Bleeker G, Tytgat GA, Adam JA, Caron HN, Kremer LC, Hooft L, van Dalen EC

      Abstract BACKGROUND: Neuroblastoma is an embryonic tumour of childhood that originates in the neural crest.

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      Mentions: Imaging MIBG
    14. New Test Shows Effectiveness of Cancer Therapy in Children

      "An important benefit of CEUS imaging is that it allows us to quantify blood flow and determine if tumors are responding to the blood vessel targeting chemotherapy, whereas the conventional method of assessing these tumors with CT and MR evaluates only changes in tumor size. The St Jude investigators found that CEUS measurements predicted which patients would respond to therapy at very early time points. The results were announced today at the annual International Contrast Ultrasound Society (ICUS) conference in Chicago."

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      Mentions: Imaging
    15. Usefulness of positron emission tomography in the differentiation between tumor and infectious lesions in pediatric oncology: a case report.

      Usefulness of positron emission tomography in the differentiation between tumor and infectious lesions in pediatric oncology: a case report.

      BMC Pediatr. 2015;15(1):108

      Authors: Tibúrcio FR, de Sá Rodrigues KE, Vasconcelos HM, Miranda DM, Simões E Silva AC

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      Mentions: Imaging
    16. Initial Experience With Gallium-68 DOTA-Octreotate PET/CT and Peptide Receptor Radionuclide Therapy for Pediatric Patients With Refractory Metastatic Neuroblastoma.

      "GaTATE PET was positive in a high proportion of patients with refractory neuroblastoma, correlating with SSTR 2 on IHC, with additional disease identified compared with MIBG imaging. PRRT seems safe, feasible, with responses observed in patients with progression despite multimodality treatment. These data support ongoing clinical trials in such patients."

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    17. MRI Scanners Can Steer Tumor Busting Viruses to Specific Target Sites Within the Body

      "An international team of researchers, led by Dr Munitta Muthana from the University of Sheffield's Department of Oncology, have now found MRI scanners can non-invasively steer cells, which have been injected with tiny super-paramagnetic iron oxide nanoparticles (SPIOs), to both primary and secondary tumour sites within the body.  This targeted approach is extremely beneficial for patients as it dramatically increases the efficiency of treatment and drug doses could potentially be reduced - helping to alleviate side effects."

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      Mentions: Staging Imaging
    18. PD-L1 Imaging

      "Antibodies that block the interaction between programmed death ligand 1 (PD-L1) and PD-1 have shown impressive antitumor activity. Patients with tumors expressing PD-L1 are most likely to respond to this treatment. The aim of our study was to develop a noninvasive imaging technique to determine tumor PD-L1 expression in vivo. This could allow selection of patients that are most likely to benefit from anti–PD-1/PD-L1 treatment and to monitor PD-L1 expression during therapy. The monoclonal antibody PD-L1.3.1 was radiolabeled with Indium-111 (111In) and characterized using PD-L1–expressing MDA-MB-231 cells."

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    19. De Novo Assessment of Pediatric Musculoskeletal Soft Tissue Tumors: Beyond Anatomic Imaging.

      1The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Medical Institutions, Baltimore, Maryland sahlawa1@jhmi.edu. 2The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Medical Institutions, Baltimore, Maryland. MRI plays a central role in the assessment of pediatric musculoskeletal soft tissue tumors.

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      Mentions: Imaging
    20. Whole-Body Pediatric Neuroblastoma Imaging: 123I-mIBG and Beyond.

      "Pediatric cancer imaging stands to benefit from higher tumor detection sensitivity without ionizing radiation exposure. A prospective protocol compared diagnostic I-metaiodobenzylguanidine (I-mIBG) with whole-body diffusion-weighted MRI (DWI) to validate adjunctive methods of identifying small-volume oligometastatic neuroblastoma tumor deposits. Dual-modality imaging (I-mIBG and DWI) was obtained within a 3- and 25-day window at baseline and again at one year in the first enrolled patient. MRI was able to define the full extent of metastatic disease foci with improved resolution. These findings may provide critical information for definitive locoregional surgery and radiotherapy for high-risk neuroblastoma treatment."

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      Mentions: Imaging MIBG
    1-24 of 31 1 2 »
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