1. Articles in category: Epigenetics and Epigenomics

    1-7 of 7
    1. Methylation of DNA and chromatin as a mechanism of oncogenesis and therapeutic target in neuroblastoma.

      Methylation of DNA and chromatin as a mechanism of oncogenesis and therapeutic target in neuroblastoma.

      Oncotarget. 2018 Apr 24;9(31):22184-22193

      Authors: Ram Kumar RM, Schor NF

      Abstract Neuroblastoma (NB), a developmental cancer, is often fatal, emphasizing the need to understand its pathogenesis and identify new therapeutic targets.

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    2. Targeting of epigenetic regulators in neuroblastoma.

      Targeting of epigenetic regulators in neuroblastoma.

      Exp Mol Med. 2018 Apr 27;50(4):51

      Authors: Jubierre L, Jiménez C, Rovira E, Soriano A, Sábado C, Gros L, Llort A, Hladun R, Roma J, Toledo JS, Gallego S, Segura MF

      Abstract Approximately 15,000 new cases of pediatric cancer are diagnosed yearly in Europe, with 8-10% corresponding to neuroblastoma, a rare disease with an incidence of 8-9 cases per million children <15 years of age.

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    3. Epigenetic regulation of neuroblastoma development.

      Epigenetic regulation of neuroblastoma development.

      Cell Tissue Res. 2018 Jan 19;:

      Authors: Kaat D, Frank S

      Abstract In recent years, technological advances have enabled a detailed landscaping of the epigenome and the mechanisms of epigenetic regulation that drive normal cell function, development and cancer.

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    4. Targeting cancer’s self-defence mechanisms

      Targeting cancer’s self-defence mechanisms

      "Overall, this suggests that cells are managing to ‘buffer’ the drug’s impact, meaning that HDAC inhibitors seem to cause relatively few changes in histone acetylation patterns in and around genes.  Our work shows, for the first time, that when normal human cells are exposed to HDAC inhibitors, they rapidly reorganise their patterns of gene activity so as to minimise the immediate effects of the drugs. This switches cells into a kind of self-defence mode, meaning that they can survive and keep growing despite the epigenetic changes induced by the treatment."

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    5. Epigenomes as Therapeutic Targets.

      "Different reports show that epigenetic modifications in whole genomes, known as the epigenome, are a key driving force in genome expression control. Such changes are increasingly recognized as major mechanisms involved in the development of a variety of diseases. Epigenetic modifications can be reversed by the use of small molecules, antibodies and inhibitors and, thus, such changes are promising targets for therapeutics. This review examines epigenetic mechanisms and the basis for targeting the epigenome to treat complex diseases."

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    6. Researchers unravel health/disease map

      "The project, called the National Institutes of Health (NIH) Roadmap Epigenomics Mapping Consortium, provides a core set of data, methodology and infrastructure for studying the epigenome's role in human health and disease. The original goal was to map 25 normal reference epigenomes, but new technology allowed the team to produce 111 highly detailed maps on how the epigenome varies and operates in different settings."

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    1-7 of 7
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