1. Articles in category: Surgery

    1-20 of 20
    1. Radical Surgery Improves Survival in Patients with Stage 4 Neuroblastoma.

      Radical Surgery Improves Survival in Patients with Stage 4 Neuroblastoma.

      World J Surg. 2017 Nov 10;:

      Authors: Vollmer K, Gfroerer S, Theilen TM, Bochennek K, Klingebiel T, Rolle U, Fiegel H

      Abstract BACKGROUND: Neuroblastoma (NBL) is the most common extracranial solid tumor in children. Despite a good overall prognosis in NBL patients, the outcome of children with stage 4 disease, even with multimodal intensive therapy, remains poor.

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      Mentions: Surgery
    2. Retrospective analysis of relapsed abdominal high-risk neuroblastoma.

      Retrospective analysis of relapsed abdominal high-risk neuroblastoma.

      J Pediatr Surg. 2017 Sep 11;:

      Authors: Dübbers M, Simon T, Berthold F, Fischer J, Volland R, Hero B, Cernaianu G

      Abstract BACKGROUND/PURPOSE: The impact of abdominal topography and surgical technique on resectability and local relapse pattern of relapsed abdominal high-risk neuroblastoma (R-HR-NB) is not clearly defined.

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      Mentions: Treatment Relapse
    3. Comparing oncologic outcomes after minimally invasive and open surgery for pediatric neuroblastoma and Wilms tumor.

      Comparing oncologic outcomes after minimally invasive and open surgery for pediatric neuroblastoma and Wilms tumor.

      Pediatr Blood Cancer. 2017 Aug 09;:

      Authors: Ezekian B, Englum BR, Gulack BC, Rialon KL, Kim J, Talbot LJ, Adibe OO, Routh JC, Tracy ET, Rice HE

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      Mentions: Surgery
    4. Complete surgical resection improves outcome in INRG high-risk patients with localized neuroblastoma older than 18 months.

      Complete surgical resection improves outcome in INRG high-risk patients with localized neuroblastoma older than 18 months.

      BMC Cancer. 2017 Aug 04;17(1):520

      Authors: Fischer J, Pohl A, Volland R, Hero B, Dübbers M, Cernaianu G, Berthold F, von Schweinitz D, Simon T

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      Mentions: INRG Imaging MYCN
    5. The role of surgery in delayed local treatment for INSS 4 neuroblastoma.

      The role of surgery in delayed local treatment for INSS 4 neuroblastoma.

      Pediatr Int. 2017 Jun 23;:

      Authors: Uehara S, Yoneda A, Oue T, Nakahata K, Zenitani M, Miyamura T, Hashii Y, Fukuzawa M, Okuyama H

      Abstract PURPOSE: The aim of the present study was to compare the efficacy, complications and outcomes of the following two different surgical strategies, in patients receiving delayed local treatment for INSS 4 neuroblastoma (NB): complete resection (CR; period A), and gross total resection (GTR)/subtotal resection (STR) with local irradiation (period B). METHODS: We retrospectively analyzed 17 patients with INSS 4 neuroblastoma (NB) who ...

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      Mentions: Treatment Surgery
    6. Image-defined risk factors for nephrectomy in patients undergoing neuroblastoma resection.

      "Encasement and narrowing of renal vessels, delayed excretion, and tumor invasion into the kidney, particularly pelvis and capsule invasion, are significantly associated with partial or total nephrectomy at initial neuroblastoma resection. These observations provide valuable information for surgical planning as well as presurgical discussions with families prior to neuroblastoma resection."

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    7. Laparoscopic Adrenalectomy is Feasible for Suspected Adrenal Tumors in Children Younger than 24 Months of Age - But is it Always Justified?

      Laparoscopic Adrenalectomy is Feasible for Suspected Adrenal Tumors in Children Younger than 24 Months of Age - But is it Always Justified?

      Klin Padiatr. 2016 Feb 29;

      Authors: Hubertus J, Pohl A, Schmid I, von Schweinitz D

      Abstract Introduction: Tumors of the adrenal gland are rare in children younger than 24 months of age. While neuroblastomas are most important in this age group, adrenal hemorrhage and other tumors are sometimes difficult to distinguish.

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      Mentions: Surgery
    8. Preoperative surgical simulation of laparoscopic adrenalectomy for neuroblastoma using a three-dimensional printed model based on preoperative CT images.

      "The multi-detector CT images were transferred to a 3D workstation, and 3D volume data were obtained by reconstructing the sections. A model was made with a 3D printer using acrylic ultraviolet curable resin. The adrenal tumor, kidney, renal vein and artery, inferior vena cava, aorta, and outer body were fabricated. The pneumoperitoneum, insertion of trocars, and laparoscopic view were all attainable in this model. We used this model for three cases with adrenal NB.  We used this model to discuss the port layout before the operation and to simulate the laparoscopic view and range of forceps movement. All three cases ...

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    9. The efficacy of delayed surgery in children with high-risk neuroblastoma.

      "The decline in tumor volume was statistically significant (P < 0.0001). Initial surgery was performed in three and delayed in 20 children, and eight children were inoperable. Surgical complication rate was 66.6% (two out of three patients) in initial surgery group; however, the rate was 15% (3 out of 20 patients) in delayed surgery group. The 5-year event-free survival and overall survival rates in the whole group were 44.8% and 50.8%, respectively. Primary tumor area control rate was 95%."

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    10. [Neonatal stage IV and IVs neuroblastoma: surgical treatment with silo and liver reduction].

      "Hepatic metastases of neonatal neuroblastoma can cause multiple organ failure due to rapid growth and severe hepatomegaly. The objective of this work is to present two infants with neuroblastoma stage IV and IVs in a critical situation that needed a decompressive abdominal silo and surgical liver reduction for definitive abdominal closure. Currently both children are 6 years old and they are free from disease."

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      Mentions: Treatment
    11. Gateway for Cancer Research℠ Funds “Tumor Paint” Clinical Trial; Open...

      "Seattle Children’s hospital opens enrollment for the first clinical trial of the phase I BLZ-100 drug. Funded by Gateway for Cancer Research, this clinical trial aims to improve the detection and removal of solid tumors without harming the surrounding healthy tissue that can lead to serious long-term side effects. BLZ-100 drug, dubbed “Tumor Paint,” uses a protein derivative of a Deathstalker Scorpion’s venom that inherently bonds to tumor cells and glows when exposed to laser light and imaged with a near-infrared camera system. This culmination of unrelated technologies now provides surgeons with a clear picture of the cancer ...

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      Mentions: Treatment
    12. Gene therapy, surgery could mean eight more months for sickest brain cancer patients

      Houston Methodist Neurological Institute neurosurgeon David Baskin, M.D., is presenting preliminary data from a phase II clinical trial that suggests gene therapy, (AdV-Tk therapy), which uses a mediated herpes simplex virus, combined with a traditional treatment -- surgical resection -- could benefit glioblastoma patients with the worst prognoses.

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    13. The role of primary tumor resection in neuroblastoma: When and how much?

      "This illustrates some of the problems with studies assessing surgical efficacy in high-risk patients, namely: primary study aims other than resection, and a lack of central imaging review. Recent prospective data from both the Children’s Oncology Group and SIOPEN, presented at the 2014 Advances in Neuroblastoma Research meeting in Cologne, support more complete resection in high-risk patients.  Incorporation of post-resection imaging and categorization analogous to preoperative IDRFs in prospective studies would assess surgical efficacy more accurately."

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      Mentions: Surgery
    14. Prechemotherapy robotic-assisted laparoscopic radical nephrectomy for an adolescent with Wilms tumor.

      Prechemotherapy robotic-assisted laparoscopic radical nephrectomy for an adolescent with Wilms tumor.

      "Herein, we describe a 14-year-old female presenting with a 1-month history of right flank pain. Subsequent work-up revealed a localized, centrally located, enhancing right renal mass. The patient underwent robotic-assisted laparoscopic radical nephrectomy and pathology demonstrated stage II, favorable histology WT. Herein, we will discuss the pertinent details regarding adolescents with renal tumors and the risks and benefits of using a minimally invasive surgical approach."

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      Mentions: Surgery
    15. Radioguided localization of neuroblastomas in laparoscopic surgery using 123 I- radiolabeled metaiodobenzylguanidine.

      "Minimally invasive surgery has become widely recognized and is commonly used for the diagnosis and treatment of neuroblastoma. However, in post-chemotherapy status or during reoperations, it is occasionally difficult to precisely locate small neuroblastoma lesions, and this becomes prominent in endoscopic surgeries, in which tactile sense is essentially lost. Herein, we report our preliminary experience in two abdominal neuroblastoma cases undergoing laparoscopic tumor resection with aid of intraoperative 123 I- metaiodobenzylguanidine (MIBG) radioguidance using a specifically designed gamma-probe. The procedure enables easier localization of viable neuroblastoma tissue, provided that the tumor shows moderate to high MIBG uptake."

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    16. Esthesioneuroblastoma: an update on the UCLA experience, 2002-2013.

      "The endoscopic approach had a statistically significant decrease in length of hospital stay and a trend toward reduced blood loss, intensive care unit admission, and complications. The modified Kadish staging was the only factor identified to predict OS. Multivariate analysis revealed that tumor grade was an independent predictor of recurrence; therefore, its importance should be emphasized in future staging systems."

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      Mentions: Treatment Surgery
    17. Role of Surgery in Stage 4 Neuroblastoma

      Data from the German GPOH NB97 study suggests that in Stage 4 patients above the age of 18 months at diagnosis complete surgical resection at the primary tumor site does not affect final outcomes. Such a finding is contrary to the natural instinct of the vast majority of parents who want all, and if not as much as possible, of their child’s tumor removed.

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      Mentions: Surgery GPOH SIOPEN
    1-20 of 20
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