1. Articles in category: Case Report

    1-24 of 61 1 2 3 »
    1. MYCN amplification predicts poor prognosis based on interphase fluorescence in situ hybridization analysis of bone marrow cells in bone marrow metastases of neuroblastoma.

      MYCN amplification predicts poor prognosis based on interphase fluorescence in situ hybridization analysis of bone marrow cells in bone marrow metastases of neuroblastoma.

      Cancer Cell Int. 2017;17:43

      Authors: Yue ZX, Huang C, Gao C, Xing TY, Liu SG, Li XJ, Zhao Q, Wang XS, Zhao W, Jin M, Ma XL

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      Mentions: MYCN Bone Marrow LDH
    2. Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.

      Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.

      Sci Data. 2017 Mar 28;4:170033

      Authors: Harenza JL, Diamond MA, Adams RN, Song MM, Davidson HL, Hart LS, Dent MH, Fortina P, Reynolds CP, Maris JM

      Abstract Neuroblastoma cell lines are an important and cost-effective model used to study oncogenic drivers of the disease.

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      Mentions: ALK MYCN
    3. Microarray expression analysis of MYCN-amplified neuroblastoma cells after inhibition of CDK2.

      Microarray expression analysis of MYCN-amplified neuroblastoma cells after inhibition of CDK2.

      Neoplasma. 2017 Mar 03;64(3):

      Authors: Song H, Wu F, Li S, Wang Z, Liu X, Cui Y, Lin C

      Abstract The study was aimed to explore the underlying molecular mechanisms of CDK2 inhibition in neuroblastoma by bioinformatics analysis. Gene expression profile GSE16480 was downloaded from the Gene Expression Omnibus.

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      Mentions: MYCN
    4. Prevalence of cardiovascular late sequelae in long-term survivors of childhood cancer: A systematic review and meta-analysis

      Cardiovascular diseases are well-known late effects of childhood cancer and research on these late effects is a highly important emerging field. We conducted a systematic review with a meta-analysis to give an overview of the current evidence and the prevalence of late cardiovascular events.

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    5. Artificial neural network classifier predicts neuroblastoma patients' outcome.

      Artificial neural network classifier predicts neuroblastoma patients' outcome.

      BMC Bioinformatics. 2016 Nov 08;17(Suppl 12):347

      Authors: Cangelosi D, Pelassa S, Morini M, Conte M, Bosco MC, Eva A, Sementa AR, Varesio L

      Abstract BACKGROUND: More than fifty percent of neuroblastoma (NB) patients with adverse prognosis do not benefit from treatment making the identification of new potential targets mandatory.

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      Mentions: Treatment
    6. Proteome and Acetylome Analysis Identifies Novel Pathways and Targets Regulated by Perifosine in Neuroblastoma.

      Proteome and Acetylome Analysis Identifies Novel Pathways and Targets Regulated by Perifosine in Neuroblastoma.

      Sci Rep. 2017 Feb 06;7:42062

      Authors: Gu X, Hua Z, Dong Y, Zhan Y, Zhang X, Tian W, Liu Z, Thiele CJ, Li Z

      Abstract Perifosine, an Akt inhibitor, has been shown to be effective in controlling neuroblastoma tumor growth. However, studies indicate that in addition to the ability to inhibit Akt, other mechanisms contribute to perifosine's anti-tumor activity.

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    7. Outcome of children with relapsed or refractory neuroblastoma: A meta-analysis of ITCC/SIOPEN European phase II clinical trials.

      Outcome of children with relapsed or refractory neuroblastoma: A meta-analysis of ITCC/SIOPEN European phase II clinical trials.

      Pediatr Blood Cancer. 2016 Aug 24;

      Authors: Moreno L, Rubie H, Varo A, Le Deley MC, Amoroso L, Chevance A, Garaventa A, Gambart M, Bautista F, Valteau-Couanet D, Geoerger B, Vassal G, Paoletti X, Pearson AD

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      Mentions: SIOPEN Refractory
    8. A case of pediatric parapharyngeal space ganglioneuroma.

      A case of pediatric parapharyngeal space ganglioneuroma.

      Ear Nose Throat J. 2016 Apr-May;95(4-5):E16-E20

      Authors: Garzorz N, Diercks GR, Lin HW, Faquin WC, Romo LV, Hartnick CJ

      Abstract Ganglioneuromas are rare, benign neoplasms derived from sympathetic neural crest progenitor cells. In the pediatric population, ganglioneuromas usually develop in the mediastinum or retroperitoneum.

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    9. Acquired Multiple Cysts of the Kidney in Neuroblastoma Survivors.

      "Acute kidney injury can occur in patients with neuroblastoma, usually as a result of thrombotic microangiopathy associated with bone marrow transplantation. End-stage renal disease is described in long-term survivors. However, in this case report, we provide what is to our knowledge the first description of multiple kidney cysts in long-term survivors of stage IV neuroblastoma. None of the 7 patients we describe with neuroblastoma and multiple kidney cysts had a family history of autosomal dominant polycystic kidney disease. Also, all lacked stigmata of tuberous sclerosis complex, von Hippel-Lindau disease, or Hadju-Cheney syndrome. Two patients progressed to end-stage renal disease; in ...

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    10. Primary pancreatic neuroblastoma presenting with opsoclonus-myoclonus syndrome.

      Primary pancreatic neuroblastoma presenting with opsoclonus-myoclonus syndrome.

      Radiol Case Rep. 2016 Mar;11(1):36-40

      Authors: Galgano S, Royal S

      Abstract Although neuroblastoma is a common solid organ malignancy in children, primary pancreatic neuroblastoma is a rare entity in children, with very few cases reported in the literature. The case discusses the presentation of a 21-month-old female presenting to the neurology clinic with ataxia and erratic eye movements.

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    11. Congenital neuroblastoma presenting with paraplegia following spinal puncture in a neonate. Case report and review of the literature.

      Congenital neuroblastoma presenting with paraplegia following spinal puncture in a neonate. Case report and review of the literature.

      Arch Pediatr. 2015 Dec 24;

      Authors: Kilani M, Hammami S, Darmoul M, Haddad S, Ben Nsir A, Mnari W, Hattab MN

      Abstract Neuroblastoma is the most common intraspinal solid tumor of childhood. Neurological deterioration due to an intratumoral hemorrhage following a spinal puncture is extremely rare.

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    12. Secondary osteosarcoma arising from osteochondroma following autologous stem cell transplantation with total-body irradiation for neuroblastoma: A case report.

      "The current study describes the case of a 17-year-old boy with osteosarcoma arising from osteochondroma of the left distal humerus, which developed following TBI. TBI was administered as part of a conditioning regimen received prior to autologous peripheral hematopoietic stem cell transplantation (HSCT) at the age of 6 years, following an initial diagnosis of neuroblastoma at the age of 5 years. The patient subsequently underwent preoperative chemotherapy followed by wide local excision and reconstruction with an extracorporeally irradiated autograft. Postoperative chemotherapy was administered, and the patient demonstrated no clinical or radiographic evidence of recurrence after 40 months of follow-up. To ...

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    13. A single center clinical analysis of children with neuroblastoma.

      "The 3-year overall survival (OS) rate of patients with stage I, II, III, IV and IVs disease was 100, 100, 65.6, 34.8 and 85.7%, respectively (P=0.02). The 3-year OS and event-free survival rates were evidently increased in patients with favorable histology compared with the rates in the patients with unfavorable histology (P=0.046 and 0.030, respectively). Univariate statistical analysis revealed that the factors significantly associated with prognosis were patient age, tumor stage and risk group (P=0.004, 0.02 and 0.001, respectively). The present study identified that tumor stage, risk group ...

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      Mentions: Treatment
    14. [Neonatal neuroblastoma complicated with a threatening tumoral hepatomegaly treated by irradiation: No sequel 20 years later].

      [Neonatal neuroblastoma complicated with a threatening tumoral hepatomegaly treated by irradiation: No sequel 20 years later].

      Cancer Radiother. 2015 Nov 9;

      Authors: Doré M, Mahé MA, Corradini N, Demoor-Goldschmidt C

      Abstract In this article, we report the case of a newborn who presented a life-threatening hepatomegaly with respiratory distress at 12days of life, complicating a metastatic neuroblastoma. Low-dose liver radiotherapy was performed in emergency in order to decompress.

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      Mentions: Radiotherapy
    15. Left Ventricular Metastasis in Neuroblastoma: A Case Report.

      Left Ventricular Metastasis in Neuroblastoma: A Case Report.

      J Pediatr Hematol Oncol. 2015 Oct 16;

      Authors: Gupta D, Srikanthan M, Lagmay J, Co-Vu JG

      Abstract Neuroblastoma is the most common extracranial solid tumor in children. Most common sites of metastases from neuroblastoma are bone marrow, bone and lymph nodes, however cardiac metastasis is rarely seen. Metastatic cardiac tumors are 20 to 40 times more common than primary cardiac tumors.

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    16. Usefulness of positron emission tomography in the differentiation between tumor and infectious lesions in pediatric oncology: a case report.

      Usefulness of positron emission tomography in the differentiation between tumor and infectious lesions in pediatric oncology: a case report.

      BMC Pediatr. 2015;15(1):108

      Authors: Tibúrcio FR, de Sá Rodrigues KE, Vasconcelos HM, Miranda DM, Simões E Silva AC

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      Mentions: Imaging
    17. Identification of GALNT14 as a novel neuroblastoma predisposition gene.

      Identification of GALNT14 as a novel neuroblastoma predisposition gene.

      Oncotarget. 2015 Jul 3;

      Authors: De Mariano M, Gallesio R, Chierici M, Furlanello C, Conte M, Garaventa A, Croce M, Ferrini S, Tonini GP, Longo L

      Abstract Although several genes have been associated to neuroblastoma (NB) predisposition and aggressiveness, further genes are likely involved in the overall risk of developing this pediatric cancer.

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      Mentions: ALK MYCN
    18. Development of port-site metastases following thoracoscopic resection of a neuroblastoma.

      "We report a 26-month-old female who developed port-site metastases of a neuroblastoma following minimally invasive thoracoscopic interventions. After diagnosis of an intrathoracic low-risk neuroblastoma and 6 months of observation, she developed respiratory problems. She subsequently underwent total resection of a locally progressive tumor via thoracoscopy. Six months later, she developed local relapse and subcutaneous metastases within the thoracic wall. These port-site metastases were most likely iatrogenic. After excision of metastases, the residual tumor responded well to salvage chemotherapy. The patient has remained in remission for over 4 years."

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      Mentions: Surgery
    19. Unusual Differentiation to Pheochromocytoma-Like Cells in an Adrenal Neuroblastoma After Chemotherapy: A Case Report and Literature Review.

      "The authors present a case of 3-year-old female with Stage 4 neuroblastoma originating from the left adrenal gland. Biopsy of the left adrenal tumor showed neuroblastoma. After three courses of chemotherapy, the left adrenal gland including the left adrenal tumor was surgically removed. Pathological findings of the resected tumor revealed that most of the neuroblastoma tissues changed to pheochromocytoma-like cells."

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      Mentions: Chemotherapy Biopsy
    20. Trametinib-induced Left Ventricular Dysfunction in a Child With Relapsed Neuroblastoma.

      "The MEK inhibitor trametinib is globally approved for metastatic melanoma harboring BRAF mutations. There are no reports thus far on its use in children. Exome sequencing on a relapsed tumor sample from an 11-year-old male with progressive, multiply relapsed stage 4 neuroblastoma revealed NRASQ61K mutation. After demonstration of normal cardiac function, he was started on oral trametinib. On day 13 of treatment, echocardiogram showed moderate left ventricular dysfunction. Trametinib was discontinued on day 15 and oral lisinopril was started. Left ventricular function recovered to baseline 37 days after discontinuing trametinib. However, neuroblastoma showed further progression."

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    21. Surgical resection and post-operative radiotherapy in an adult renal neuroblastoma patient with multiple bone and joint metastases: A case report.

      Abstract: Renal neuroblastoma is uncommon, particularly in adults, with only a few cases having been reported in studies published in the English language. The incidence is only 0.12 cases/1 million individuals in those aged >20 years.

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    22. Right adrenal gland neuroblastoma infiltrating the liver and mimicking mesenchymal hamartoma: A case report.

      INTRODUCTION: Neuroblastoma is the most common extracranial solid pediatric malignancy. The most common site is abdomen with predominance of suprarenal medulla. Infiltration of the tumour to the liver is rare. No cases were reported in the literature about the misdiagnosis of neuroblastoma as mesenchymal hamartoma in the liver.

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    1-24 of 61 1 2 3 »
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    1. (2 articles) MYCN
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