Using droplet digital PCR to analyze MYCN and ALK copy number in plasma from patients with neuroblastoma.
Oncotarget. 2017 Jul 07;:
Authors: Lodrini M, Sprüssel A, Astrahantseff K, Tiburtius D, Konschak R, Lode HN, Fischer M, Keilholz U, Eggert A, Deubzer HE
Shallow whole genome sequencing on circulating cell-free DNA allows reliable non-invasive copy number profiling in neuroblastoma patients.
Clin Cancer Res. 2017 Jul 14;:
Authors: Van Roy N, Van der Linden M, Menten B, Dheedene A, Vandeputte C, Van Dorpe J, Laureys G, Renard M, Sante T, Lammens T, De Wilde B, Speleman F, De Preter K
Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression.
Proc Natl Acad Sci U S A. 2017 Jul 10;:
Authors: Westerlund I, Shi Y, Toskas K, Fell SM, Li S, Surova O, Södersten E, Kogner P, Nyman U, Schlisio S, Holmberg J
Conditions : Advanced Malignant Solid Neoplasm; FGFR1 Gene Mutation; FGFR2 Gene Mutation; FGFR3 Gene Mutation; FGFR4 Gene Mutation; Histiocytosis; Recurrent Central Nervous System Neoplasm; Recurrent Childhood Non-Hodgkin Lymphoma; Recurrent Malignant Solid Neoplasm; Recurrent Neuroblastoma; Refractory Central Nervous System Neoplasm; Refractory Malignant Solid Neoplasm; Refractory Neuroblastoma; Refractory Non-Hodgkin Lymphoma; Stage III Childhood Non-Hodgkin Lymphoma; Stage IV Childhood Non-Hodgkin Lymphoma Interventions : Other: Laboratory Biomarker Analysis; Drug: pan-FGFR Tyrosine Kinase Inhibitor JNJ-42756493; Other: Pharmacological Study Sponsor : National Cancer Institute (NCI) Not yet recruiting - verified June 2017
Assessment of Anti-Tumor Cytotoxic Activity of Naturally Occurring Antibodies in Human Serum or Plasma.
Methods Mol Biol. 2017;1643:105-110
Authors: Schwartz-Albiez R, Dill O
Abstract A small percentage of the Western population carries antibodies in the peripheral blood, which are able to kill human tumors such as neuroblastoma or melanoma. Several observations indicate that these antibodies, preferentially of IgM isotype, belong to the class of naturally occurring antibodies.
The functional variant rs34330 of CDKN1B is associated with risk of neuroblastoma.
J Cell Mol Med. 2017 Jun 30;:
Authors: Capasso M, McDaniel LD, Cimmino F, Cirino A, Formicola D, Russell MR, Raman P, Cole KA, Diskin SJ
Abstract The genetic aetiology of sporadic neuroblastoma is still largely unknown.
Neuroblastoma in children: Update on clinicopathologic and genetic prognostic factors.
Pediatr Hematol Oncol. 2017 Jun 29;:1-21
Authors: Ahmed AA, Zhang L, Reddivalla N, Hetherington M
Abstract Neuroblastoma is the most common extracranial solid tumor in childhood accounting for 8-10% of all childhood malignancies. The tumor is characterized by a spectrum of histopathologic features and a heterogeneous clinical phenotype.
Genetic variations appear to pre-dispose children to developing certain severe forms of neuroblastoma, according to new research by the University of Chicago Medicine.
The findings lay the groundwork for developing more targeted treatments for...
Genetic variations appear to pre-dispose children to developing certain severe forms of neuroblastoma, according to new research. The findings lay the groundwork for developing more targeted treatments for particularly deadly variations of the cancer.
The Pediatric Cancer Working Group of the AACR released its first consensus screening guidelines for children with common cancer predisposition syndromes.
( University of Chicago Medical Center ) Genetic variations appear to pre-dispose children to developing certain severe forms of neuroblastoma, according to new research by the University of Chicago Medicine. The findings lay the groundwork for developing more targeted treatments for particularly deadly variations of the cancer.
Genomic analysis-integrated whole-exome sequencing of neuroblastomas identifies genetic mutations in axon guidance pathway.
Oncotarget. 2017 May 23;:
Authors: Li Y, Ohira M, Zhou Y, Xiong T, Luo W, Yang C, Li X, Gao Z, Zhou R, Nakamura Y, Kamijo T, Kaneko Y, Taketani T, Ueyama J, Tajiri T, Zhang H, Wang J, Yang H, Yin Y, Nakagawara A
PHILADELPHIA — The American Association for Cancer Research (AACR) has published its first set of consensus screening recommendations for children with common cancer predisposition syndromes in Clinical Cancer Research, a journal of the AACR. These recommendations emerged from the Childhood Cancer Predisposition Workshop held by the AACR Pediatric Cancer Working Group in October 2016.
Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma.
PLoS Genet. 2017 May 18;13(5):e1006787
Authors: McDaniel LD, Conkrite KL, Chang X, Capasso M, Vaksman Z, Oldridge DA, Zachariou A, Horn M, Diamond M, Huo C, Iolascon A, Hakonarson H, Rahman N, Devoto M, Diskin SJ
A new study has served to identify some genetic mutations that will help to improve the treatment of neuroblastoma.
DNA sequences from 100-year-old tumor samples could bolster childhood cancer research -- Read more on ScientificAmerican.com
Genetic susceptibility to neuroblastoma.
Curr Opin Genet Dev. 2017 Apr 27;42:81-90
Authors: Tolbert VP, Coggins GE, Maris JM
Abstract Until recently, the genetic basis of neuroblastoma, a heterogeneous neoplasm arising from the developing sympathetic nervous system, remained undefined.
TERT-mediated and ATRX-mediated Telomere Maintenance and Neuroblastoma.
J Pediatr Hematol Oncol. 2017 Apr 27;:
Authors: Duan XF, Zhao Q
Abstract Neuroblastomas (NB) are one of the most common extracranial solid tumors in children, and they frequently display high heterogeneity in the disease course. With ongoing research, more information regarding the genetic etiology and molecular mechanisms underlying these contrasting phenotypes is being uncovered.
HSD17B12 gene rs11037575 C>T polymorphism confers neuroblastoma susceptibility in a Southern Chinese population.
Onco Targets Ther. 2017;10:1969-1975
Authors: Zhang Z, Zou Y, Zhu J, Zhang R, Yang T, Wang F, Xia H, He J, Feng Z
Abstract A previous genome-wide association study (GWAS) identified four genetic polymorphisms (rs1027702 near DUSP12, rs10055201 in IL31RA, rs2619046 in DDX4, and rs11037575 in HSD17B12 gene) that were associated with neuroblastoma susceptibility, especially for low-risk subjects. The aim of this study was to examine the association between these four polymorphisms and neuroblastoma susceptibility in a Southern Chinese population composed of 256 cases ...
Immunoassays for the quantification of ALK and phosphorylated ALK support the evaluation of on-target ALK inhibitors in neuroblastoma.
Mol Oncol. 2017 Apr 22;:
Authors: Tucker ER, Tall JR, Danielson LS, Gowan S, Jamin Y, Robinson SP, Banerji U, Chesler L
PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma.
Oncogene. 2017 Apr 10;:
Authors: Colicchia V, Petroni M, Guarguaglini G, Sardina F, Sahún-Roncero M, Carbonari M, Ricci B, Heil C, Capalbo C, Belardinilli F, Coppa A, Peruzzi G, Screpanti I, Lavia P, Gulino A, Giannini G
The first large-scale whole-genome sequencing study of childhood cancer survivors shows that around 12% have mutations that increase cancer risk. Medscape Medical News
WASHINGTON, April 3, 2017 /PRNewswire/ -- Twelve percent of childhood cancer survivors carry germline mutations that put them or their children at increased risk of developing cancer, according to a landmark study presented today at the annual meeting of the American Association for...
Next-generation sequencing reveals germline mutations in an infant with synchronous occurrence of nephro- and neuroblastoma.
Pediatr Hematol Oncol. 2016 May;33(4):264-75
Authors: Theruvath J, Russo A, Kron B, Paret C, Wingerter A, El Malki K, Neu MA, Alt F, Staatz G, Stein R, Seidmann L, Prawitt D, Faber J