Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance.
Sci Rep. 2018 Jul 03;8(1):10039
Authors: Ridinger J, Koeneke E, Kolbinger FR, Koerholz K, Mahboobi S, Hellweg L, Gunkel N, Miller AK, Peterziel H, Schmezer P, Hamacher-Brady A, Witt O, Oehme I
The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines.
Arch Toxicol. 2018 Jun 09;:
Authors: Kolbinger FR, Koeneke E, Ridinger J, Heimburg T, Müller M, Bayer T, Sippl W, Jung M, Gunkel N, Miller AK, Westermann F, Witt O, Oehme I
The ICR’s Professor Mel Greaves has been awarded a prestigious prize from the Memorial Sloan Kettering Cancer Center in New York for his ground-breaking research and expertise in childhood leukaemia.
Ben-Gurion University of the Negev (BGU) and Soroka University Medical Center researchers in Beer-Sheva, Israel are developing a cell culture system that for the first time can change testicular stem cells into sperm-like cells that may enable future fertility for boys with prepubertal cancer.
Plasma cell-free DNA quantification is highly correlated to tumor burden in children with neuroblastoma.
Cancer Med. 2018 Jun 14;:
Authors: Wang X, Wang L, Su Y, Yue Z, Xing T, Zhao W, Zhao Q, Duan C, Huang C, Zhang D, Jin M, Cheng X, Chen S, Liu Y, Ma X
Neuroblastoma is a pediatric cancer of the sympathetic nervous system where MYCN amplification is a key indicator of poor prognosis. However, mechanisms by which MYCN promotes neuroblastoma tumorigenesis are not fully understood. In this study, we analyzed global miRNA and mRNA expression profiles of tissues at different stages of tumorigenesis from TH-MYCN transgenic mice, a model of MYCN-driven neuroblastoma.
Metachronous Medulloblastoma in a Child With Successfully Treated Neuroblastoma: Case Report and Novel Findings of DNA Sequencing.
J Natl Compr Canc Netw. 2018 Jun;16(6):683-691
Authors: Eterovic AK, Maher OM, Chandra J, Chen K, Huse J, Zaky W
Abstract Metachronous neoplasms have rarely been reported in patients with neuroblastoma.
Study reveals an unexpected role for a well-known protein machinery in maintaining the correct DNA content with implications for cancer and other diseases.
Association of Common Genetic Variants in Pre-microRNAs and Neuroblastoma Susceptibility: A Two-Center Study in Chinese Children.
Mol Ther Nucleic Acids. 2018 Jun 01;11:1-8
Authors: He J, Zou Y, Liu X, Zhu J, Zhang J, Zhang R, Yang T, Xia H
Abstract Neuroblastoma is a commonly occurring extracranial pediatric solid tumor without defined etiology. Polymorphisms in pre-miRNAs have been demonstrated to associate with the risk of several cancers.
Methylation of DNA and chromatin as a mechanism of oncogenesis and therapeutic target in neuroblastoma.
Oncotarget. 2018 Apr 24;9(31):22184-22193
Authors: Ram Kumar RM, Schor NF
Abstract Neuroblastoma (NB), a developmental cancer, is often fatal, emphasizing the need to understand its pathogenesis and identify new therapeutic targets.
MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma.
Oncotarget. 2018 Apr 17;9(29):20323-20338
Authors: Agarwal S, Milazzo G, Rajapakshe K, Bernardi R, Chen Z, Barberi E, Koster J, Perini G, Coarfa C, Shohet JM
Abstract The MYC oncogenes and p53 have opposing yet interrelated roles in normal development and tumorigenesis. How MYCN expression alters the biology and clinical responsiveness of pediatric neuroblastoma remains poorly defined.
An international team of researchers from the Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ), the European Molecular Biology Laboratory (EMBL) and the German Cancer Consortium (DKTK) together with colleagues at the St. Jude Children’s Research Hospital in Memphis and the Hospital for Sick Children in Toronto has summarized hereditary gene defects which can […]
The post Genetic analysis for certain childhood brain tumors soon a standard-of-care? appeared first on Healthcanal.com.
Chromatin Immunoprecipitation and DNA Sequencing Identified a LIMS1/ILK Pathway Regulated by LMO1 in Neuroblastoma.
Cancer Genomics Proteomics. 2018 May-Jun;15(3):165-174
Authors: Saeki N, Saito A, Sugaya Y, Amemiya M, Ono H, Komatsuzaki R, Yanagihara K, Sasaki H
BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma.
Cell Death Dis. 2018 Apr 24;9(5):458
Authors: Sime W, Niu Q, Abassi Y, Masoumi KC, Zarrizi R, Køhler JB, Kjellström S, Lasorsa VA, Capasso M, Fu H, Massoumi R
Abstract BRCA1-associated protein 1 (BAP1) is a nuclear deubiquitinating enzyme that is associated with multiprotein complexes that regulate key cellular pathways, including cell cycle, cellular differentiation, cell death, and the DNA damage response.
Too many targets, not enough patients: rethinking neuroblastoma clinical trials.
Nat Rev Cancer. 2018 Apr 09;:
Authors: Fletcher JI, Ziegler DS, Trahair TN, Marshall GM, Haber M, Norris MD
Abstract Neuroblastoma is a rare solid tumour of infancy and early childhood with a disproportionate contribution to paediatric cancer mortality and morbidity.
The majority of high-risk neuroblastoma patients are refractory to, or relapse on, current treatment regimens, resulting in 5-year survival rates of less than 50%. This emphasizes the urgent need to identify novel therapeutic targets. Here, we report that high PIM kinase expression is correlated with poor overall survival. Treatment of neuroblastoma cell lines with the pan-PIM inhibitors AZD1208 or PIM-447 suppressed proliferation through inhibition of mTOR signaling.
Genetic susceptibility to neuroblastoma: current knowledge and future directions.
Cell Tissue Res. 2018 Mar 27;:
Authors: Ritenour LE, Randall MP, Bosse KR, Diskin SJ
Abstract Neuroblastoma, a malignancy of the developing peripheral nervous system that affects infants and young children, is a complex genetic disease. Over the past two decades, significant progress has been made toward understanding the genetic determinants that predispose to this often lethal childhood cancer.
Monoclonal antibodies that have the ability to selectively target cancer cells by binding to specific tumor-associated antigens have carved out an important role in anticancer therapy.
A rare mediastinal occurrence of neuroblastoma in an adult: case report.
Sao Paulo Med J. 2018 Mar 05;:0
Authors: Yanik F, Karamustafaoglu YA, Yoruk Y
Abstract CONTEXT: Neuroblastoma is the most common extracranial malignant solid tumor that occurs during childhood. It arises from primitive cells and is seen in the adrenal medulla and sympathetic ganglia of the sympathetic nervous system.
The mutational landscape of MYCN, Lin28b and ALKF1174L driven murine neuroblastoma mimics human disease.
Oncotarget. 2018 Feb 02;9(9):8334-8349
Authors: De Wilde B, Beckers A, Lindner S, Kristina A, De Preter K, Depuydt P, Mestdagh P, Sante T, Lefever S, Hertwig F, Peng Z, Shi LM, Lee S, Vandermarliere E, Martens L, Menten B, Schramm A, Fischer M, Schulte J, Vandesompele J, Speleman F
Researchers led by Professor Stefan Pfister from the “Hopp Children’s Cancer Center at the NCT Heidelberg” (KiTZ) have been able to draw an extremely detailed molecular map of childhood cancers. In close collaboration with the German Cancer Consortium (DKTK) and the Society for Pediatric Oncology and Hematology (GPOH), they screened almost 1,000 tumor samples from […]
The post A molecular map of childhood cancers appeared first on Healthcanal.com.
Association between NEFL Gene Polymorphisms and Neuroblastoma Risk in Chinese Children: A Two-Center Case-Control Study.
J Cancer. 2018;9(3):535-539
Authors: Wu Q, Zhuo ZJ, Zeng J, Zhang J, Zhu J, Zou Y, Zhang R, Yang T, Zhu D, He J, Xia H
Abstract Neuroblastoma is a lethal tumor that mainly occurs in children. To date, the genetic etiology of sporadic neuroblastoma remains obscure.
Whole exome sequencing reveals novel somatic alterations in neuroblastoma patients with chemotherapy.
Cancer Cell Int. 2018;18:21
Authors: Duan C, Wang H, Chen Y, Chu P, Xing T, Gao C, Yue Z, Zheng J, Jin M, Gu W, Ma X
Abstract Background: We ought to explore the acquired somatic alterations, shedding light on genetic basis of somatic alterations in NB patients with chemotherapy.
Investigation of major genetic alterations in neuroblastoma.
Mol Biol Rep. 2018 Feb 17;:
Authors: Costa RA, Seuánez HN
Abstract Neuroblastoma (NB) is the most common extracranial solid tumor in childhood. This malignancy shows a wide spectrum of clinical outcome and its prognosis is conditioned by manifold biological and genetic factors.