1. Articles in category: Genomics

    1-24 of 262 1 2 3 4 ... 9 10 11 »
    1. Accumulation of potential driver genes with genomic alterations predicts survival of high-risk neuroblastoma patients.

      Accumulation of potential driver genes with genomic alterations predicts survival of high-risk neuroblastoma patients.

      Biol Direct. 2018 Jul 16;13(1):14

      Authors: Suo C, Deng W, Vu TN, Li M, Shi L, Pawitan Y

      Abstract BACKGROUND: Neuroblastoma is the most common pediatric malignancy with heterogeneous clinical behaviors, ranging from spontaneous regression to aggressive progression.

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      Mentions: MYCN
    2. Somatic mutations in specific and connected sub-pathways are associated to short neuroblastoma patients' survival and indicate proteins targetable at onset of disease.

      Somatic mutations in specific and connected sub-pathways are associated to short neuroblastoma patients' survival and indicate proteins targetable at onset of disease.

      Int J Cancer. 2018 Jul 11;:

      Authors: Esposito MR, Binatti A, Pantile M, Coppe A, Mazzocco K, Longo L, Capasso M, Lasorsa VA, Luksch R, Bortoluzzi S, Tonini GP

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    3. St. Jude Children’s Research Hospital launches public repository of pediatric cancer genomics data

      St. Jude Children’s Research Hospital launches public repository of pediatric cancer genomics data

      Jinghui ZhangPhoto credit: St. Jude Children’s Research Hospital St. Jude Children’s Research Hospital launched an online data-sharing platform that includes more than 4,000 whole-genome sequencing data sets from three pediatric cohorts. St. Jude Cloud — created in partnership with Microsoft and DNAnexus — gives researchers access to next-generation sequencing data and unique analysis tools for the advancement of research efforts for pediatric diseases. “St.

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      Mentions: Genetics
    4. New method to preserve boy cancer patient fertility being developed

      New method to preserve boy cancer patient fertility being developed

      Ben-Gurion University of the Negev (BGU) and Soroka University Medical Center researchers in Beer-Sheva, Israel are developing a cell culture system that for the first time can change testicular stem cells into sperm-like cells that may enable future fertility for boys with prepubertal cancer.

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      Mentions: Genetics
    5. Network Modeling of microRNA-mRNA Interactions in Neuroblastoma Tumorigenesis Identifies miR-204 as a Direct Inhibitor of MYCN

      Network Modeling of microRNA-mRNA Interactions in Neuroblastoma Tumorigenesis Identifies miR-204 as a Direct Inhibitor of MYCN

      Neuroblastoma is a pediatric cancer of the sympathetic nervous system where MYCN amplification is a key indicator of poor prognosis. However, mechanisms by which MYCN promotes neuroblastoma tumorigenesis are not fully understood. In this study, we analyzed global miRNA and mRNA expression profiles of tissues at different stages of tumorigenesis from TH-MYCN transgenic mice, a model of MYCN-driven neuroblastoma.

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      Mentions: Imaging MYCN Genetics
    6. Metachronous Medulloblastoma in a Child With Successfully Treated Neuroblastoma: Case Report and Novel Findings of DNA Sequencing.

      Metachronous Medulloblastoma in a Child With Successfully Treated Neuroblastoma: Case Report and Novel Findings of DNA Sequencing.

      J Natl Compr Canc Netw. 2018 Jun;16(6):683-691

      Authors: Eterovic AK, Maher OM, Chandra J, Chen K, Huse J, Zaky W

      Abstract Metachronous neoplasms have rarely been reported in patients with neuroblastoma.

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      Mentions: ALK
    7. Childhood cancer: The four survival strategies of tumor cells

      Childhood cancer: The four survival strategies of tumor cells

      ( Lund University ) Cancer cells in children tend to develop by following four main trajectories -- and two of them are linked to relapse of the disease, research led by Lund University in Sweden shows. The four strategies can occur simultaneously in a single tumor, according to the study that is now published in Nature Genetics.

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      Mentions: Relapse Genetics
    8. Association of Common Genetic Variants in Pre-microRNAs and Neuroblastoma Susceptibility: A Two-Center Study in Chinese Children.

      Association of Common Genetic Variants in Pre-microRNAs and Neuroblastoma Susceptibility: A Two-Center Study in Chinese Children.

      Mol Ther Nucleic Acids. 2018 Jun 01;11:1-8

      Authors: He J, Zou Y, Liu X, Zhu J, Zhang J, Zhang R, Yang T, Xia H

      Abstract Neuroblastoma is a commonly occurring extracranial pediatric solid tumor without defined etiology. Polymorphisms in pre-miRNAs have been demonstrated to associate with the risk of several cancers.

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    9. Methylation of DNA and chromatin as a mechanism of oncogenesis and therapeutic target in neuroblastoma.

      Methylation of DNA and chromatin as a mechanism of oncogenesis and therapeutic target in neuroblastoma.

      Oncotarget. 2018 Apr 24;9(31):22184-22193

      Authors: Ram Kumar RM, Schor NF

      Abstract Neuroblastoma (NB), a developmental cancer, is often fatal, emphasizing the need to understand its pathogenesis and identify new therapeutic targets.

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    10. Genetic analysis for certain childhood brain tumors soon a standard-of-care?

      Genetic analysis for certain childhood brain tumors soon a standard-of-care?

      An international team of researchers from the Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ), the European Molecular Biology Laboratory (EMBL) and the German Cancer Consortium (DKTK) together with colleagues at the St. Jude Children’s Research Hospital in Memphis and the Hospital for Sick Children in Toronto has summarized hereditary gene defects which can […]

      The post Genetic analysis for certain childhood brain tumors soon a standard-of-care? appeared first on Healthcanal.com.

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    11. Predicting neuroblastoma using developmental signals and a logic-based model.

      Predicting neuroblastoma using developmental signals and a logic-based model.

      Biophys Chem. 2018 Apr 30;238:30-38

      Authors: Kasemeier-Kulesa JC, Schnell S, Woolley T, Spengler JA, Morrison JA, McKinney MC, Pushel I, Wolfe LA, Kulesa PM

      Abstract Genomic information from human patient samples of pediatric neuroblastoma cancers and known outcomes have led to specific gene lists put forward as high risk for disease progression.

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    12. Chromatin Immunoprecipitation and DNA Sequencing Identified a LIMS1/ILK Pathway Regulated by LMO1 in Neuroblastoma.

      Chromatin Immunoprecipitation and DNA Sequencing Identified a LIMS1/ILK Pathway Regulated by LMO1 in Neuroblastoma.

      Cancer Genomics Proteomics. 2018 May-Jun;15(3):165-174

      Authors: Saeki N, Saito A, Sugaya Y, Amemiya M, Ono H, Komatsuzaki R, Yanagihara K, Sasaki H

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      Mentions: Genetics
    13. St. Jude Cloud, largest public repository of pediatric cancer genomics data, launches for researchers worldwide

      St. Jude Cloud, largest public repository of pediatric cancer genomics data, launches for researchers worldwide

      MEMPHIS, Tenn. and MOUNTAIN VIEW, Calif., April 12, 2018 /PRNewswire/ -- St. Jude Children's Research Hospital today launched St. Jude Cloud, an online data-sharing and collaboration platform that provides researchers access to the world's largest public repository of pediatric cancer...

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      Mentions: Genetics
    14. PIM Kinases Are a Potential Prognostic Biomarker and Therapeutic Target in Neuroblastoma

      PIM Kinases Are a Potential Prognostic Biomarker and Therapeutic Target in Neuroblastoma

      The majority of high-risk neuroblastoma patients are refractory to, or relapse on, current treatment regimens, resulting in 5-year survival rates of less than 50%. This emphasizes the urgent need to identify novel therapeutic targets. Here, we report that high PIM kinase expression is correlated with poor overall survival. Treatment of neuroblastoma cell lines with the pan-PIM inhibitors AZD1208 or PIM-447 suppressed proliferation through inhibition of mTOR signaling.

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    15. Genetic susceptibility to neuroblastoma: current knowledge and future directions.

      Genetic susceptibility to neuroblastoma: current knowledge and future directions.

      Cell Tissue Res. 2018 Mar 27;:

      Authors: Ritenour LE, Randall MP, Bosse KR, Diskin SJ

      Abstract Neuroblastoma, a malignancy of the developing peripheral nervous system that affects infants and young children, is a complex genetic disease. Over the past two decades, significant progress has been made toward understanding the genetic determinants that predispose to this often lethal childhood cancer.

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      Mentions: ALK PHOX2B
    16. A rare mediastinal occurrence of neuroblastoma in an adult: case report.

      A rare mediastinal occurrence of neuroblastoma in an adult: case report.

      Sao Paulo Med J. 2018 Mar 05;:0

      Authors: Yanik F, Karamustafaoglu YA, Yoruk Y

      Abstract CONTEXT: Neuroblastoma is the most common extracranial malignant solid tumor that occurs during childhood. It arises from primitive cells and is seen in the adrenal medulla and sympathetic ganglia of the sympathetic nervous system.

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    17. The mutational landscape of MYCN, Lin28b and ALKF1174L driven murine neuroblastoma mimics human disease.

      The mutational landscape of MYCN, Lin28b and ALKF1174L driven murine neuroblastoma mimics human disease.

      Oncotarget. 2018 Feb 02;9(9):8334-8349

      Authors: De Wilde B, Beckers A, Lindner S, Kristina A, De Preter K, Depuydt P, Mestdagh P, Sante T, Lefever S, Hertwig F, Peng Z, Shi LM, Lee S, Vandermarliere E, Martens L, Menten B, Schramm A, Fischer M, Schulte J, Vandesompele J, Speleman F

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      Mentions: ALK MYCN
    18. A molecular map of childhood cancers

      A molecular map of childhood cancers

      Researchers led by Professor Stefan Pfister from the “Hopp Children’s Cancer Center at the NCT Heidelberg” (KiTZ) have been able to draw an extremely detailed molecular map of childhood cancers. In close collaboration with the German Cancer Consortium (DKTK) and the Society for Pediatric Oncology and Hematology (GPOH), they screened almost 1,000 tumor samples from […]

      The post A molecular map of childhood cancers appeared first on Healthcanal.com.

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      Mentions: GPOH Genetics
    1-24 of 262 1 2 3 4 ... 9 10 11 »
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