1. Articles in category: Children & Families

    1-24 of 53 1 2 3 »
    1. Pain in Children with Cancer: Prevalence, Characteristics, and Parent Management.

      Pain in Children with Cancer: Prevalence, Characteristics, and Parent Management.

      Clin J Pain. 2017 Jul 03;:

      Authors: Tutelman PR, Chambers CT, Stinson JN, Parker JA, Fernandez CV, Witteman HO, Nathan PC, Barwick M, Campbell F, Jibb LA, Irwin K

      Abstract OBJECTIVES: Pain is a common and distressing symptom of pediatric cancer, as reported by both children and their parents.

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    2. Treatment of Transient Peripheral Neuropathy During Chimeric 14.18 Antibody Therapy in Children With Neuroblastoma: A Case Series.

      Treatment of Transient Peripheral Neuropathy During Chimeric 14.18 Antibody Therapy in Children With Neuroblastoma: A Case Series.

      J Pediatr Hematol Oncol. 2017 Jul 03;:

      Authors: Ari P, Kars M, Meany H, Pestieau S

      Abstract Children with high-risk neuroblastoma are currently treated with a chimeric monoclonal antibody against GD2 ganglioside (chimeric 14.18). The treatment improves survival but causes transient neuropathic pain-like syndrome.

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      Mentions: Antibody Treatment
    3. Bromodomain and extraterminal protein inhibitors in pediatrics: A review of the literature.

      Bromodomain and extraterminal protein inhibitors in pediatrics: A review of the literature.

      Pediatr Blood Cancer. 2017 May;64(5):

      Authors: Jiménez I, Baruchel A, Doz F, Schulte J

      Abstract The last few years have seen the identification of pharmacologic approaches to target bromodomain and extraterminal (BET) proteins for cancer treatment.

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      Mentions: Treatment
    4. New biomarker assay detects neuroblastoma with greater sensitivity

      New biomarker assay detects neuroblastoma with greater sensitivity

      ( Children's Hospital Los Angeles ) Investigators at The Saban Research Institute of Children's Hospital Los Angeles have developed and tested a new biomarker assay for quantifying disease and detecting the presence of neuroblastoma even when standard evaluations yield negative results for the disease.

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      Mentions: NANT MIBG
    5. Potential for more targeted treatments of neuroblastoma tumors

      Genetic variations appear to pre-dispose children to developing certain severe forms of neuroblastoma, according to new research. The findings lay the groundwork for developing more targeted treatments for particularly deadly variations of the cancer.

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      Mentions: MYCN
    6. Altered erythropoiesis and decreased number of erythrocytes in children with neuroblastoma.

      Altered erythropoiesis and decreased number of erythrocytes in children with neuroblastoma.

      Oncotarget. 2017 May 30;:

      Authors: Morandi F, Barco S, Stigliani S, Croce M, Persico L, Lagazio C, Scuderi F, Belli ML, Montera M, Cangemi G, Pozzi S, Rigo V, Scaruffi P, Amoroso L, Erminio G, Pistoia V, Ferrini S, Corrias MV

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    7. New research points to potential for more targeted treatments of neuroblastoma tumors

      New research points to potential for more targeted treatments of neuroblastoma tumors

      ( University of Chicago Medical Center ) Genetic variations appear to pre-dispose children to developing certain severe forms of neuroblastoma, according to new research by the University of Chicago Medicine. The findings lay the groundwork for developing more targeted treatments for particularly deadly variations of the cancer.

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      Mentions: MYCN
    8. Giving children a voice in clinical trials

      Giving children a voice in clinical trials

      ( Children's National Health System ) Children as young as 8 years old with incurable cancer can reliably characterize the impact an experimental therapy has on their symptoms and quality of life -- even at the earliest stages of drug development -- making self-reported patient outcomes a potential new clinical trial endpoint.

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    9. Clinical manifestations of neuroblastoma with head and neck involvement in children.

      Clinical manifestations of neuroblastoma with head and neck involvement in children.

      Int J Pediatr Otorhinolaryngol. 2017 Jun;97:157-162

      Authors: Alvi S, Karadaghy O, Manalang M, Weatherly R

      Abstract OBJECTIVE: The purpose of our study is to review our 15-year experience with pediatric patients who have been diagnosed with neuroblastoma, and to determine their most frequent head and neck manifestations and symptoms. STUDY DESIGN: Retrospective chart review of electronic medical record.

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    10. A phase 1 study of the c-Met inhibitor, tivantinib (ARQ197) in children with relapsed or refractory solid tumors: A Children's Oncology Group study phase 1 and pilot consortium trial (ADVL1111)

      The c-Met receptor tyrosine kinase is dysregulated in many pediatric cancers. Tivantinib is an oral small molecule that inhibits the c-Met receptor tyrosine kinase. A phase 1 and pharmacokinetic (PK) trial evaluating tivantinib was conducted in children with relapsed/refractory solid tumors.

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      Mentions: COG Refractory
    11. High-risk neuroblastoma in a sub-Saharan African country: telling it like it is.

      High-risk neuroblastoma in a sub-Saharan African country: telling it like it is.

      Trop Doct. 2017 Jan 01;:49475517704363

      Authors: Hadley GP, van Heerden J

      Abstract Neuroblastoma is uncommon in Africa, but when seen usually presents as high-risk disease with a poor prognosis. This aggressive biology of the tumour is frequently augmented by delayed presentation.

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    12. Study finds more childhood cancer survivors would likely benefit from genetic screening

      Study finds more childhood cancer survivors would likely benefit from genetic screening

      WASHINGTON, April 3, 2017 /PRNewswire/ -- Twelve percent of childhood cancer survivors carry germline mutations that put them or their children at increased risk of developing cancer, according to a landmark study presented today at the annual meeting of the American Association for...

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    13. The importance of oncologists giving hope

      Previous article in Early View: Impact of shared care program in follow-up of childhood cancer survivors: An intervention study

      Previous article in Early View: Impact of shared care program in follow-up of childhood cancer survivors: An intervention study

      Next article in Early View: Infectious complications in children with acute lymphoblastic leukemia treated with the Taiwan Pediatric Oncology Group protocol: A 16-year tertiary single-institution experience

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    14. ICR scientists awarded £1.5m precision medicine funding for targeted, less toxic childhood cancer treatments

      ICR scientists awarded £1.5m precision medicine funding for targeted, less toxic childhood cancer treatments

      Scientists from The Institute of Cancer Research, London, have been awarded £1.5 million by the charity Children with Cancer UK to advance precision medicine in the UK and improve cancer treatment for children and young adults.

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      Mentions: Treatment
    15. Cancer in children adversely affects parents' income and employment

      "The researchers found that parents’ income from employment decreased significantly following a child’s cancer diagnosis, with an overall 21 percent reduction in mothers’ earnings and a 10 percent reduction in fathers’ earnings for the year of diagnosis when compared with control parents.  The relative reduction in income of mothers was evident up to six years post-diagnosis, whereas fathers’ income was reduced for two years post-diagnosis."

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    16. Assessment of quality of life of children and adolescents with cancer during their treatment.

      Assessment of quality of life of children and adolescents with cancer during their treatment.

      Jpn J Clin Oncol. 2016 Feb 16;

      Authors: Vlachioti E, Matziou V, Perdikaris P, Mitsiou M, Stylianou C, Tsoumakas K, Moschovi M

      Abstract OBJECTIVE: The purpose of this study was to evaluate the quality of life of children and adolescents with any type of cancer in all phases of their treatment.

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      Mentions: Treatment
    17. Parents of children with cancer may suffer post-traumatic stress for several years

      "Among parents of children who survived cancer, about 19% of mothers and 8% of fathers experienced partial post-traumatic stress disorder (PTSD) 5 years after treatment concluded. Among parents whose children died of cancer, 20% of mothers and 35% of fathers reported PTSD 5 years after their child’s death.  “Our study shows the threats to family for years after the initial treatment,” Louise von Essen, PhD, professor of clinical psychology in health care at Uppsala University in Sweden, told HemOnc Today. “For bereaved parents, and particularly mothers, trauma is most severe and impressive. However, parents of the children considered successfully ...

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      Mentions: Treatment
    1-24 of 53 1 2 3 »
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