1. Articles in category: General

    1-24 of 272 1 2 3 4 ... 10 11 12 »
    1. Chemoimmunotherapeutic effect of combined treatment with ex vivo generated antigen-presenting immune cells and conventional antitumor agents in a mouse neuroblastoma model.

      Chemoimmunotherapeutic effect of combined treatment with ex vivo generated antigen-presenting immune cells and conventional antitumor agents in a mouse neuroblastoma model.

      J Pediatr Surg. 2017 Apr 21;:

      Authors: Inoue S, Setoyama Y, Odaka A, Kitagawa D, Beck Y

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      Mentions: Treatment
    2. The second-generation ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma cells and inhibits tumor growth in a TH-MYCN transgenic neuroblastoma mouse model.

      The second-generation ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma cells and inhibits tumor growth in a TH-MYCN transgenic neuroblastoma mouse model.

      Cancer Lett. 2017 Apr 25;:

      Authors: Lu J, Guan S, Zhao Y, Yu Y, Woodfield SE, Zhang H, Yang KL, Bieerkehazhi S, Qi L, Li X, Gu J, Xu X, Jin J, Muscal JA, Yang T, Xu GT, Yang J

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      Mentions: ALK MYCN
    3. Impact of shared care program in follow-up of childhood cancer survivors: An intervention study

      With the growing rate of childhood cancer cure and the risks of sequelae, long-term follow-up (FU) of survivors is a central issue. Several models have been proven far from satisfactory. Shared care FU is the result of collaboration between general practitioners (GPs) and cancer centers. We sought to demonstrate the feasibility of setting up a shared care program based on the patient-centered education of GPs and to evaluate the impact of this model in an intervention study.

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    4. Next-generation sequencing reveals germline mutations in an infant with synchronous occurrence of nephro- and neuroblastoma.

      Next-generation sequencing reveals germline mutations in an infant with synchronous occurrence of nephro- and neuroblastoma.

      Pediatr Hematol Oncol. 2016 May;33(4):264-75

      Authors: Theruvath J, Russo A, Kron B, Paret C, Wingerter A, El Malki K, Neu MA, Alt F, Staatz G, Stein R, Seidmann L, Prawitt D, Faber J

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      Mentions: ALK
    5. Prominent Pulmonary Metastases Without Concurrent Osseous Involvement in Patients With High-Risk Neuroblastoma.

      Prominent Pulmonary Metastases Without Concurrent Osseous Involvement in Patients With High-Risk Neuroblastoma.

      Clin Nucl Med. 2017 Feb 13;:

      Authors: Bai X, Zhuang H

      Abstract Metastases from high-risk neuroblastomas generally are to the bone or bone marrow. Multiple lung metastases are rare, especially when there was no concurrent osseous metastasis. We report 2 cases of high-risk neuroblastomas having prominent lung metastases without concurrent osseous lesion observed.

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    6. Parent illness appraisals, parent adjustment, and parent-reported child quality of life in pediatric cancer.

      "The goal of the present study was to examine the interrelationships among multiple parent illness appraisals, parent adjustment outcomes, and parent-reported child quality of life in parents of children diagnosed with cancer. Parents completed measures of illness appraisal (illness uncertainty and attitude toward illness), parent adjustment (general distress, posttraumatic stress, parenting stress), and child quality of life (general and cancer-related). Path analysis revealed direct effects for parent illness uncertainty and illness attitudes on all 3 measures of parent adjustment. Illness uncertainty, but not illness attitudes, demonstrated a direct effect on parent-reported child general quality of life; parenting stress had direct ...

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    7. Medical management of side effects related to CAR T cell therapy in hematologic malignancies.

      Medical management of side effects related to CAR T cell therapy in hematologic malignancies.

      Expert Rev Hematol. 2016 May 3;

      Authors: Namuduri M, Brentjens RJ

      Abstract CD19-targeted Chimeric Antigen Receptor (CAR) T cells have shown impressive success and drastically improved clinical outcomes in relapsed/refractory B-cell malignancies, especially acute lymphoblastic leukemia. However, some unique, mostly reversible toxicities are observed with this novel immunotherapeutic approach.

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      Mentions: Side Effects
    8. Feasibility of Early Palliative Care Consultation for Children With High-Risk Malignancies

      Children with cancer suffer significant morbidity throughout therapy and often face an uncertain prognosis. Because palliative care teams can provide an additional layer of support with symptom management and communication, we conducted a prospective study assessing the feasibility of early palliative care consultation for children with high-risk malignancies.

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    9. News digest – Cancer’s ‘Achilles heel’, e-cigs, vegan diets and… condoms cause cancer?

      News digest – Cancer’s ‘Achilles heel’, e-cigs, vegan diets and… condoms cause cancer?
      • Our scientists uncovered a potential ‘Achilles heel’ on the surface of cancer cells, which helps give us important clues that could one day lead to personalised treatments using patients’ own immune systems. The BBC, Guardian, Financial Times and many more covered this story. And here’s our press release and blog post for the full scoop on the story.
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    10. Phase I Study of Random Healthy Donor-Derived Allogeneic Natural Killer Cell Therapy in Patients with Malignant Lymphoma or Advanced Solid Tumors

      Natural killer (NK) cells with mismatched killer cell immunoglobulin-like receptor–ligand pairs have shown efficacy and been proven safe in treatment of cancer patients. Ex vivo–expanded and highly activated NK cells (MG4101) had been generated under good manufacturing practice conditions, which demonstrated potent anticancer activity in vitro and in vivo in preclinical studies.

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      Mentions: NK Cells
    11. PD-1 Blockade Expands Intratumoral Memory T Cells

      Tumor responses to programmed cell death protein 1 (PD-1) blockade therapy are mediated by T cells, which we characterized in 102 tumor biopsies obtained from 53 patients treated with pembrolizumab, an antibody to PD-1. Biopsies were dissociated, and single-cell infiltrates were analyzed by multicolor flow cytometry using two computational approaches to resolve the leukocyte phenotypes at the single-cell level.

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      Mentions: Antibody PD-1
    12. Cancer MoonShot 2020 Announces the Formation of a National Pediatrics Consortium, a Major Milestone in the War on Cancer in Children

      PHOENIX--(BUSINESS WIRE)--In a press conference today, Cancer MoonShot 2020 announced another milestone in its quest to alter the course of cancer care with the formation of the Pediatrics Consortium focused on bringing the promise of combined immunotherapy as the next-generation standard of cancer care to children diagnosed with the disease. With leadership at Phoenix Children’s Hospital helping to initiate this consortium, all founding partners will seek to apply the most comprehensive cancer

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      Mentions: Immunotherapy
    13. Immunotherapy cancer ‘cure’ headlines distract from fascinating science

      Immunotherapy cancer ‘cure’ headlines distract from fascinating science

      The undoubted promise of cancer immunotherapy is never far from the headlines. And waking up this morning, we heard claims that a new immune therapy may offer hope of ‘lasting cures’ for cancer.

      The news comes from a conference in Washington DC in the US. And while the science is extremely exciting, the media’s response has jumped the gun a little.

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      Mentions: Immunotherapy
    14. "NextGen" Biologics: Bispecific Antibodies and Emerging Clinical Results.

      "NextGen" Biologics: Bispecific Antibodies and Emerging Clinical Results.

      Expert Opin Biol Ther. 2016 Feb 5;

      Authors: Thakur A, Lum LG

      Abstract FUNDING SOURCE: Funding was supported by National Cancer Institute of the NIH under award numbers CA092344, CA140314, and Young Family Foundation and the Raymond Neag Foundation. CONFLICT OF INTEREST: L.G.L. is co-founder of Transtarget Inc. and A.T. is co-founder of Nova Immune Platform.

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    15. The rapid enrollment design for Phase I clinical trials.

      The rapid enrollment design for Phase I clinical trials.

      Stat Med. 2016 Feb 1;

      Authors: Ivanova A, Wang Y, Foster MC

      Abstract We propose a dose-finding design for Phase I oncology trials where each new patient is assigned to the dose most likely to be the target dose given observed data. The main model assumption is that the dose-toxicity curve is non-decreasing. This method is beneficial when it is desirable to assign a patient to a dose as soon as the patient is enrolled into a study.

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    16. Physician Perspectives on Palliative Care for Children With Neuroblastoma: An International Context.

      Physician Perspectives on Palliative Care for Children With Neuroblastoma: An International Context.

      Pediatr Blood Cancer. 2016 Jan 19;

      Authors: Balkin EM, Thompson D, Colson KE, Lam CG, Matthay KK

      Abstract BACKGROUND: Studies have shown that children with cancer globally lack access to palliative care. Little is known regarding physicians' perceptions of palliative care, treatment access, and self-reported competence in providing palliative care.

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    17. Targeting hedgehog signaling pathway in pediatric tumors: in vitro evaluation of SMO and GLI inhibitors.

      Targeting hedgehog signaling pathway in pediatric tumors: in vitro evaluation of SMO and GLI inhibitors.

      Cancer Chemother Pharmacol. 2016 Jan 19;

      Authors: Arnhold V, Boos J, Lanvers-Kaminsky C

      Abstract PURPOSE: The successful use of SMO inhibitors in tumors with activating mutations in hedgehog signaling raised interests in their exploitation against other malignancies. The role of hedgehog signaling in pediatric malignancies remains unclear.

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    18. Different Aspects of Psychological Ill Health in a National Sample of Swedish Parents after Successful Paediatric Stem Cell Transplantation

      Paediatric hematopoietic stem cell transplantation (HSCT) may have great psychological impact on parents during the intense treatment period as well as many years after a successful transplantation. Since different psychological disorders require different interventions, a differentiation of general distress into specific types of psychological ill health is essential.

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    19. Physician Perspectives on Palliative Care for Children With Neuroblastoma: An International Context

      Studies have shown that children with cancer globally lack access to palliative care. Little is known regarding physicians’ perceptions of palliative care, treatment access, and self-reported competence in providing palliative care.

      Members of the Global Neuroblastoma Network (online tumor board) were surveyed. Eighty-three respondents met inclusion criteria; 53 (64%) completed the survey.

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      Mentions: Treatment
    1-24 of 272 1 2 3 4 ... 10 11 12 »
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