1. Articles in category: News

    1-24 of 153 1 2 3 4 5 6 7 »
    1. Moringa isothiocyanate complexed with α-cyclodextrin: a new perspective in neuroblastoma treatment.

      Moringa isothiocyanate complexed with α-cyclodextrin: a new perspective in neuroblastoma treatment.

      BMC Complement Altern Med. 2017 Jul 14;17(1):362

      Authors: Giacoppo S, Iori R, Rollin P, Bramanti P, Mazzon E

      Abstract BACKGROUND: Several lines of evidence suggest the consume of natural products for cancer prevention or treatment. In particular, isothiocyanates (ITCs) exerting anti-cancer properties, have received great interest as potential chemotherapeutic agents.

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      Mentions: Treatment LDH
    2. New potential treatment for aggressive types of childhood cancer

      New potential treatment for aggressive types of childhood cancer

      A combination of substances that impacts chemical modifications in the DNA of tumours and triggers the tumours to differentiate into harmless nerve cells could represent a new method of treating aggressive forms of neuroblastoma. The new method has been proposed by researchers at Karolinska Institutet, after studies using mice showed that the combination treatment resulted in a significant suppression in tumour growth.

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      Mentions: Treatment
    3. New biomarker assay detects neuroblastoma with greater sensitivity

      Investigators have developed and tested a new biomarker assay for quantifying disease and detecting the presence of neuroblastoma even when standard evaluations yield negative results for the disease. Researchers provide the first systematic comparison of standard imaging evaluations versus the new assay that screens for five different neuroblastoma-associated genes and determine that the new assay improves disease assessment and provides prediction of disease progression.

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      Mentions: NANT Imaging MIBG
    4. New biomarker assay detects neuroblastoma with greater sensitivity

      New biomarker assay detects neuroblastoma with greater sensitivity

      ( Children's Hospital Los Angeles ) Investigators at The Saban Research Institute of Children's Hospital Los Angeles have developed and tested a new biomarker assay for quantifying disease and detecting the presence of neuroblastoma even when standard evaluations yield negative results for the disease.

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      Mentions: NANT MIBG
    5. New research points to potential targeted treatments of neuroblastoma tumours

      New research points to potential targeted treatments of neuroblastoma tumours

      Genetic variations appear to pre-dispose children to developing certain severe forms of neuroblastoma, according to new research by the University of Chicago Medicine.

      The findings lay the groundwork for developing more targeted treatments for...

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      Mentions: MYCN
    6. Potential for more targeted treatments of neuroblastoma tumors

      Genetic variations appear to pre-dispose children to developing certain severe forms of neuroblastoma, according to new research. The findings lay the groundwork for developing more targeted treatments for particularly deadly variations of the cancer.

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      Mentions: MYCN
    7. Accelerating Drug Development for Neuroblastoma - New Drug Development Strategy: An Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Europe Neu

      "The current drug development model has been slow, associated with significant attrition, and few new drugs have been developed for neuroblastoma. The Neuroblastoma New Drug Development Strategy (NDDS) has: 1) established a group with expertise in drug development; 2) prioritised targets and drugs according to tumour biology (target expression, dependency, pre-clinical data; potential combinations; biomarkers), identifying as priority targets ALK, MEK, CDK4/6, MDM2, MYCN (druggable by BET bromodomain, aurora kinase, mTORC1/2) BIRC5 and checkpoint kinase 1; 3) promoted clinical trials with target-prioritised drugs. Drugs showing activity can be rapidly transitioned via parallel randomised trials into front-line studies. Expert ...

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      Mentions: ALK MYCN
    8. In vitro assay for measuring real time topotecan release from liposomes: release kinetics and cellular internalization.

      In vitro assay for measuring real time topotecan release from liposomes: release kinetics and cellular internalization.

      Drug Deliv Transl Res. 2017 Apr 21;:

      Authors: Gilabert-Oriol R, Chernov L, Anantha M, Dragowska WH, Bally MB

      Abstract Topotecan is a drug that is under investigation for the treatment of neuroblastoma and has been encapsulated into liposomes to improve its therapeutic efficacy.

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      Mentions: Treatment
    9. Appeal On Refusal Of Children’s Cancer Treatment Upheld Solving Kids’ Cancer Successfully Challenges NICE Decision

      Appeal On Refusal Of Children’s Cancer Treatment Upheld Solving Kids’ Cancer Successfully Challenges NICE Decision

      "The National Institute for Health and Care Excellence (NICE) has today announced that it has upheld the appeal by Solving Kids’ Cancer against the Institute’s decision not to recommend dinutuximab for treating high-risk neuroblastoma. The decision on whether to recommend dinutuximab will now be referred back to the Appraisal Committee for reconsideration. Solving Kids’ Cancer had argued that NICE had exceeded its powers and was in breach of the UN Convention on the Rights of the Child, and that using a 10-year cure point as the basis for the drug’s effectiveness was unreasonable given the evidence before it."

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      Mentions: Treatment
    10. Car T cell therapy can now target solid tumors: Mouse study

      Car T cell therapy can now target solid tumors: Mouse study

      "The cancer cell marker that Johnson and her team identified was a specific change in protein glycosylation, that is, a unique pattern of sugars decorating a protein found on the cell surface. In collaboration with investigators from the University of Copenhagen and University of Chicago, the researchers developed novel CAR T cells that express a monoclonal antibody called 5E5, which specifically recognizes a sugar modification--the Tn glycan on the mucin 1 (MUC1) protein--that is absent on normal cells but abundant specifically on cancer cells."

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      Mentions: Immunotherapy
    11. Buster Posey to help fight pediatric cancer

      Buster Posey to help fight pediatric cancer

      "It's not acceptable," Posey said as he sat at a table with his wife, Giants president and CEO Larry Baer and New Era president and CEO Chris Koch. "We said we've got to do something. We can't sit here and talk about how bad this, we've got to try to help." At one point Posey choked back tears as he talked about Cannon Wiggins, a 4-year-old who had recently been diagnosed with neuroblastoma.

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    12. Stand Up To Cancer Launches "Catalyst," a New Research Program Supported by Industry

      "Under the SU2C Catalyst program, companies like Merck, Bristol-Myers Squibb and Genentech will donate funds to support collaborative research studies using products the companies will provide, such as new pharmaceutical compounds that they are developing or approved agents that can be investigated for other uses.  

      Through its scientific partner, the American Association for Cancer Research (AACR), SU2C will issue a Request for Proposals (RFP) to the scientific community based on each company's commitment of funding and materials such as drugs and diagnostic tests. The RFP will lay out the compounds that will be available, the research emphasis, the estimated ...

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    13. Mathematics to Fight Cancer

      Mathematics to Fight Cancer

      "The initial results show that treatment with several types of immune cells could in fact be a promising approach", says the lead scientist of this work, Prof. Dr. Anton Bovier of the Hausdorff Center for Mathematics. The studies are based on a stochastic model from the area of adaptive dynamics, which was developed by the mathematicians for application, for example, in cancer research. "Tumors are nothing other than populations of cancer cells, which interact with one another in a very complex manner and react to their environment in the form of the body and its immune system", explains Prof. Bovier.

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    14. News digest – Cancer’s ‘Achilles heel’, e-cigs, vegan diets and… condoms cause cancer?

      News digest – Cancer’s ‘Achilles heel’, e-cigs, vegan diets and… condoms cause cancer?
      • Our scientists uncovered a potential ‘Achilles heel’ on the surface of cancer cells, which helps give us important clues that could one day lead to personalised treatments using patients’ own immune systems. The BBC, Guardian, Financial Times and many more covered this story. And here’s our press release and blog post for the full scoop on the story.
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    1-24 of 153 1 2 3 4 5 6 7 »
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