1. Articles in category: News

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    1. In vitro assay for measuring real time topotecan release from liposomes: release kinetics and cellular internalization.

      In vitro assay for measuring real time topotecan release from liposomes: release kinetics and cellular internalization.

      Drug Deliv Transl Res. 2017 Apr 21;:

      Authors: Gilabert-Oriol R, Chernov L, Anantha M, Dragowska WH, Bally MB

      Abstract Topotecan is a drug that is under investigation for the treatment of neuroblastoma and has been encapsulated into liposomes to improve its therapeutic efficacy.

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      Mentions: Treatment
    2. Appeal On Refusal Of Children’s Cancer Treatment Upheld Solving Kids’ Cancer Successfully Challenges NICE Decision

      Appeal On Refusal Of Children’s Cancer Treatment Upheld Solving Kids’ Cancer Successfully Challenges NICE Decision

      "The National Institute for Health and Care Excellence (NICE) has today announced that it has upheld the appeal by Solving Kids’ Cancer against the Institute’s decision not to recommend dinutuximab for treating high-risk neuroblastoma. The decision on whether to recommend dinutuximab will now be referred back to the Appraisal Committee for reconsideration. Solving Kids’ Cancer had argued that NICE had exceeded its powers and was in breach of the UN Convention on the Rights of the Child, and that using a 10-year cure point as the basis for the drug’s effectiveness was unreasonable given the evidence before it."

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      Mentions: Treatment
    3. Car T cell therapy can now target solid tumors: Mouse study

      Car T cell therapy can now target solid tumors: Mouse study

      "The cancer cell marker that Johnson and her team identified was a specific change in protein glycosylation, that is, a unique pattern of sugars decorating a protein found on the cell surface. In collaboration with investigators from the University of Copenhagen and University of Chicago, the researchers developed novel CAR T cells that express a monoclonal antibody called 5E5, which specifically recognizes a sugar modification--the Tn glycan on the mucin 1 (MUC1) protein--that is absent on normal cells but abundant specifically on cancer cells."

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      Mentions: Immunotherapy
    4. Buster Posey to help fight pediatric cancer

      Buster Posey to help fight pediatric cancer

      "It's not acceptable," Posey said as he sat at a table with his wife, Giants president and CEO Larry Baer and New Era president and CEO Chris Koch. "We said we've got to do something. We can't sit here and talk about how bad this, we've got to try to help." At one point Posey choked back tears as he talked about Cannon Wiggins, a 4-year-old who had recently been diagnosed with neuroblastoma.

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    5. Stand Up To Cancer Launches "Catalyst," a New Research Program Supported by Industry

      "Under the SU2C Catalyst program, companies like Merck, Bristol-Myers Squibb and Genentech will donate funds to support collaborative research studies using products the companies will provide, such as new pharmaceutical compounds that they are developing or approved agents that can be investigated for other uses.  

      Through its scientific partner, the American Association for Cancer Research (AACR), SU2C will issue a Request for Proposals (RFP) to the scientific community based on each company's commitment of funding and materials such as drugs and diagnostic tests. The RFP will lay out the compounds that will be available, the research emphasis, the estimated ...

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    6. Mathematics to Fight Cancer

      Mathematics to Fight Cancer

      "The initial results show that treatment with several types of immune cells could in fact be a promising approach", says the lead scientist of this work, Prof. Dr. Anton Bovier of the Hausdorff Center for Mathematics. The studies are based on a stochastic model from the area of adaptive dynamics, which was developed by the mathematicians for application, for example, in cancer research. "Tumors are nothing other than populations of cancer cells, which interact with one another in a very complex manner and react to their environment in the form of the body and its immune system", explains Prof. Bovier.

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    7. News digest – Cancer’s ‘Achilles heel’, e-cigs, vegan diets and… condoms cause cancer?

      News digest – Cancer’s ‘Achilles heel’, e-cigs, vegan diets and… condoms cause cancer?
      • Our scientists uncovered a potential ‘Achilles heel’ on the surface of cancer cells, which helps give us important clues that could one day lead to personalised treatments using patients’ own immune systems. The BBC, Guardian, Financial Times and many more covered this story. And here’s our press release and blog post for the full scoop on the story.
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    8. Pediatrics Data Platform Announced at White House Precision Medicine Initiative

      “The ‘big data’ genomics revolution presents us with unprecedented opportunities to improve treatments for pediatric brain tumors, which are the leading cause of disease-related death in children,” said Phillip Storm, M.D., division chief of Neurosurgery at CHOP and the Center’s co-director.  CHOP’s commitment to PMI is the product of collaborative efforts in pediatric cancer research that include a national network of more than 15 leading hospitals, numerous industry partners, foundations, patients and their families. The Cavatica system is central to these efforts, integrating a cloud-based, open infrastructure with big data analytics so that researchers can leverage a ...

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      Mentions: Genetics
    9. Searching for cancer's fingerprints gives clues to tumour growth

      Searching for cancer's fingerprints gives clues to tumour growth

      "However, to overcome these low oxygen conditions, cancer cells need to evolve alternative ways to produce energy; controlled by a range of signalling molecules, most importantly Hypoxia Inducible Factors (HIFs).  The latest research from a research group at The University of Manchester looked at cells in various oxygen environments and compared their metabolic fingerprint - the hallmarks of energy production. The team explored those features linked to HIF and those that acted independently, in two different types of cancer cell, in order to fully understand how each process interacted.  Professor Kaye Williams, who led the study, said: "If we deprive cells ...

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    10. Gene therapy: T cells target mutations to fight solid tumors

      Gene therapy: T cells target mutations to fight solid tumors

      "Now, in a publication in the Journal of Clinical Investigation, the Berlin researchers show the importance of preliminary animal studies to ensure the final success of mutation-specific therapies. Even if some mutations appear to be suitable targets for therapy after tests in cell cultures, they can have disappointing results in the real context of a patient's body. The research group of Thomas Blankenstein and Wolfgang Uckert were able to analyze the antigens and clearly distinguish between "good" and "bad" T cell targets by using a humanized mouse model. "This means that we have developed an animal model to test ...

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    11. Immunotherapy cancer ‘cure’ headlines distract from fascinating science

      Immunotherapy cancer ‘cure’ headlines distract from fascinating science

      The undoubted promise of cancer immunotherapy is never far from the headlines. And waking up this morning, we heard claims that a new immune therapy may offer hope of ‘lasting cures’ for cancer.

      The news comes from a conference in Washington DC in the US. And while the science is extremely exciting, the media’s response has jumped the gun a little.

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      Mentions: Immunotherapy
    12. Stopping tumor cells killing surrounding tissue may provide clue to fighting cancer

      ( University of Cambridge ) Cancer cells kill off surrounding cells to make room to grow, according to new research from the University of Cambridge. Although the study was carried out using fruit flies, its findings suggest that drugs to prevent, rather than encourage, cell death might be effective at fighting cancer -- contrary to how many of the current chemotherapy drugs work.

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    13. New Research from Memorial Sloan Kettering Highlights Fertility Concerns of Young Adult and Adolescent Cancer Survivors

      New Rochelle, NY —Nearly half of young adult survivors of adolescent cancers--more young men than women--report uncertainty about their fertility, according to the results of a new study. While females were more likely to describe feeling distressed and overwhelmed and tended to worry more about pregnancy-related health risks and cancer recurrence, both sexes had concerns about genetic risk factors and how infertility might impact their future lives, as described in the study published in Journal of Adolescent and Young Adult Oncology (JAYAO), a multidisciplinary peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free on the JAYAO ...

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