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Anti-GD2 Immunoliposomes for Targeted Delivery of the Survivin Inhibitor Sepantronium Bromide (YM155) to Neuroblastoma Tumor Cells.

ncbi.nlm.nih.gov

Anti-GD2 Immunoliposomes for Targeted Delivery of the Survivin Inhibitor Sepantronium Bromide (YM155) to Neuroblastoma Tumor Cells.

Pharm Res. 2018 Mar 07;35(4):85

Authors: Gholizadeh S, Dolman EM, Wieriks R, Sparidans RW, Hennink WE, Kok RJ

Abstract PURPOSE: Sepantronium bromide (YM155) is a hydrophilic quaternary compound that cannot be administered orally due to its low oral bioavailability; it is furthermore rapidly eliminated via the kidneys.