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GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3.
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PIM kinases are a potential prognostic biomarker and therapeutic target in neuroblastoma.

ncbi.nlm.nih.gov

PIM kinases are a potential prognostic biomarker and therapeutic target in neuroblastoma.

Mol Cancer Ther. 2018 Feb 13;:

Authors: Brunen D, de Vries RC, Lieftink C, Beijersbergen RL, Bernards R

Abstract The majority of high-risk neuroblastoma patients are refractory to, or relapse on current treatment regimens, resulting in 5-year survival rates of less than 50%. This emphasizes the urgent need to identify novel therapeutic targets.

Mentions: Treatment Relapse Refractory