S-trityl-L-cysteine, a novel Eg5 inhibitor, is a potent chemotherapeutic strategy in neuroblastoma.
Oncol Lett. 2018 Jul;16(1):1023-1030
Authors: Wu W, Jingbo S, Xu W, Liu J, Huang Y, Sheng Q, Lv Z
Abstract Eg5 is a member of the kinesin-5 family. It is involved in the formation of the bipolar spindle and serves a crucial role in mitosis; meaning that mitotic activation may serve as a chemotherapeutic strategy.