1. PIM Kinases Are a Potential Prognostic Biomarker and Therapeutic Target in Neuroblastoma

    PIM Kinases Are a Potential Prognostic Biomarker and Therapeutic Target in Neuroblastoma

    The majority of high-risk neuroblastoma patients are refractory to, or relapse on, current treatment regimens, resulting in 5-year survival rates of less than 50%. This emphasizes the urgent need to identify novel therapeutic targets. Here, we report that high PIM kinase expression is correlated with poor overall survival. Treatment of neuroblastoma cell lines with the pan-PIM inhibitors AZD1208 or PIM-447 suppressed proliferation through inhibition of mTOR signaling.

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