Origin and initiation mechanisms of neuroblastoma.
Cell Tissue Res. 2018 Feb 14;:
Authors: Tsubota S, Kadomatsu K
Abstract Neuroblastoma is an embryonal malignancy that affects normal development of the adrenal medulla and paravertebral sympathetic ganglia in early childhood. Extensive studies have revealed the molecular characteristics of human neuroblastomas, including abnormalities at genome, epigenome and transcriptome levels.