Dualistic Role of BARD1 in Cancer.
Genes (Basel). 2017 Dec 08;8(12):
Authors: Cimmino F, Formicola D, Capasso M
Abstract BRCA1 Associated RING Domain 1 (BARD1) encodes a protein which interacts with the N-terminal region of BRCA1 in vivo and in vitro. The full length (FL) BARD1 mRNA includes 11 exons and encodes a protein comprising of six domains (N-terminal RING-finger domain, three Ankyrin repeats and two C-terminal BRCT domains) with different functions.