Hypoxia and hypoxia-inducible factors in neuroblastoma.
Cell Tissue Res. 2017 Oct 14;:
Authors: Påhlman S, Mohlin S
Abstract Hypoxia (i.e., low oxygen levels) is a known feature of aggressive tumors. Cells, including tumor cells, respond to conditions of insufficient oxygen by activating a transcriptional program mainly driven by hypoxia-inducible factors (HIF)-1 and HIF-2.