1. Promising Drug Combination Silences the Rage of Graft-Versus-Host Disease

    To pass the nearly 180 days she was a patient in Seattle Children's Cancer Unit with graft-versus-host disease (GVHD), London Bowater took orders from her doctors, nurses and other patients and families for friendship bracelets that she would braid from her hospital bed.

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    1. Her hair was falling out and her intestines were hemorrhaging blood, yet somehow my little ray of sunshine still managed to stay positive and touch all the amazing doctors and nurses with her kindness.
    2. We were about halfway home from the airport in Seattle when London said she wasn't feeling well.
    3. Every time we take a child to transplant, our greatest hope is to cure their disease.
    4. We're getting better at controlling effector T cells, but it's a very high bar to find a therapeutic strategy that both can reign in the effector T cells and allow regulatory T cells to flourish.
    5. Here, we show how KY1005 silences the signaling that activates effector T cells while leaving regulatory T-cell function untouched.
    6. In all my years, I've never seen a combination as successful at controlling GVHD as this.
    7. I still wear the bracelet London made for me as a reminder that no child should have to experience graft-versus-host disease.
    8. The GVHD took a greater toll than cancer or the transplant itself.
    9. I know there are a lot of kids that aren't as fortunate as London.
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