Manipulation of variables in local controlled release vincristine treatment in neuroblastoma.
J Pediatr Surg. 2017 Sep 04;:
Authors: Coburn JM, Harris J, Cunningham R, Zeki J, Kaplan DL, Chiu B
Abstract INTRODUCTION: Local drug delivery minimizes systemic toxicity while delivering high-dose chemotherapy for neuroblastoma patients. We hypothesized that varying burst and maintenance dosing of implanted silk platforms would improve survival.