When LMO1 Meets MYCN, Neuroblastoma Is Metastatic.
Cancer Cell. 2017 Sep 11;32(3):273-275
Authors: Liu Z, Thiele CJ
Abstract LMO1 is a high-risk neuroblastoma susceptibility gene, but how LMO1 cooperates with MYCN in neuroblastoma tumorigenesis is unclear. In this issue of Cancer Cell, Zhu et al. develop a novel zebrafish model that elucidates a mechanism by which LMO1 and MYCN synergistically initiate neuroblastoma and contribute to metastatic disease progression.