YAP promotes tumorigenesis and cisplatin resistance in neuroblastoma.
Oncotarget. 2017 Mar 15;:
Authors: Yang C, Tan J, Zhu J, Wang S, Wei G
Abstract The transcriptional co-activator Yes-associated protein (YAP) is essential for Hippo pathway-driven tumorigenesis in various cancers. However, the expression and function of YAP in neuroblastoma remains elusive. Here, we show that YAP was highly expressed in Neuroblastoma (NB) and expression levels correlated with advanced tumor staging.