1. Safe and Effective Treatment of Experimental Neuroblastoma and Glioblastoma Using Systemically Delivered Triple MicroRNA-Detargeted Oncolytic Semliki Forest Virus

    Alerts Cancer Therapy: Preclinical Safe and Effective Treatment of Experimental Neuroblastoma and Glioblastoma Using Systemically Delivered Triple MicroRNA-Detargeted Oncolytic Semliki Forest Virus Mohanraj Ramachandran , Di Yu , Matheus Dyczynski , Sathishkumar Baskaran , Lei Zhang , Aleksei Lulla , Valeria Lulla , Sirle Saul , Sven Nelander , Anna Dimberg , Andres Merits , Justyna Leja-Jarblad and Magnus Essand Mohanraj Ramachandran PDF Abstract Background: Glioblastoma multiforme and high-risk neuroblastoma are cancers with poor outcome. Immunotherapy in the form of neurotropic oncolytic viruses is a promising therapeutic approach for these malignancies. Here we evaluate the oncolytic capacity of the neurovirulent and partly IFN╬▓-resistant Semliki Forest virus (SFV)-4 in glioblastoma multiformes ...

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