1. New type of cell movement discovered

    New type of cell movement discovered

    "They found that the nucleus is actually pulled forward by the actin filaments that connect the nucleus to the front of the cell. This movement "pressurizes" the cell. The scientists were also able to identify the protein components responsible for moving the nuclear piston, including actomyosin, vimentin and nesprin."

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  2. Quotes

    1. Our work elucidated a highly intriguing question: how cells move when they are in the complex and physiologically relevant environment of a 3-D extracellular matrix.
    2. We think it's a very important normal physiological mechanism of cell movement that has not been characterized previously.
    3. When a cell is in the matrix, the nucleus tends to be at the back of the cell, and the cell body is very tubular in shape.
    4. The pressure itself is what pushes the plasma membrane.
    5. It might give us leverage to find out what is unique about cancer cells so we can target them therapeutically and not affect normal cells.
    6. This work illustrates how the physical structure of the matrix can influence cellular properties to govern biological function.