1. Targeted therapy one step closer in neuroblastoma research

    Targeted therapy one step closer in neuroblastoma research

    "Principal investigator for the Harry Perkins Institute of Medical Research and the University of Western Australia, Archa Fox says there are two new findings; the novel long noncoding RNA and the NonO protein, which along with N-Myc, contributes to severity of the cancer.  “NonO is an oncoprotein in this cancer, it’s a bad guy and we are using our knowledge and tools to work on targeting it therapeutically,” Dr Fox says.  High levels of novel long noncoding RNA and NonO expression in children who suffer from neuroblastoma, results in poor patient outcome.  Dr Fox says they are both new ...

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  2. Quotes

    1. Neuroblastoma is the most common solid tumour in early childhood and it accounts for 15 per cent of all childhood cancer death.
    2. In Australia, cancer is the most common cause of death from disease for children, and neuroblastoma is one of the most devastating types.
    3. Normally humans only have two copies of N-Myc gene but in children who have neuroblastoma they have 100-150 copies.
    4. We have confirmed the novel long noncoding RNA amplifies the expression of N-Myc oncogene.
    5. NonO is an oncoprotein in this cancer, it's a bad guy and we are using our knowledge and tools to work on targeting it therapeutically.
    6. If they are inhibited it will slow down and hopefully kill the cancer cells, this should make the world of difference for these children with this type of neuroblastoma.