1. International Neuroblastoma Research and Collaboration for Effective Delivery (INBRACED) Initiative

    International Neuroblastoma Research and Collaboration for Effective Delivery (INBRACED) Initiative

    James Calvert, Research Officer

    International Neuroblastoma Research and Collaboration for Effective Delivery (INBRACED) is a collaboration between charities, clinicians, and researchers with the shared aim of accelerating the development of new, more effective therapies for the childhood cancer neuroblastoma. Funding innovative research which promotes lasting remission in neuroblastoma is crucial as a large percentage of children with the cancer either do not respond to treatment or suffer dangerous relapse. Clinical trials often represent the best option for children in this situation and around 60% of them now participate in trials once finishing standard treatment.

    Our annual targeted Request for Proposals (RFP) is a major focus for funding pioneering research through this initiative. The process involves the INBRACED team assessing current unmet research needs alongside preclinical data and prioritising those novel proposals which show the most promise. Once proposals have been received and assessed by the team an international scientific review board of clinicians discuss the proposed projects, give their views and score each one in terms of feasibility and rationale. The RFP specifies that the project must be neuroblastoma focussed (although projects that may translate for other solid tumours will be well received); the project must also have sites in both the United States and the United Kingdom. The benefits of a trans-Atlantic trial include increasing access to trials for children in the UK and abroad as well as ensuring recruitment targets are met in a timely manner.

    INBRACED forms partnerships with existing charities and consortia to increase participation and international cooperation in clinical trials. Research advocacy is vital in the field of neuroblastoma and INBRACED offers a unique platform for charity partners to be part of the procedure and influence the projects that are funded through the partnership. By joining our global network members will be part of discussions which aim to avoid duplication and cooperate effectively. Different network members will be engaged to collaborate on the projects most relevant to their particular expertise. All parties will be kept aware of joint projects and given an open forum in which to discuss current , upcoming, and potential projects.

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